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Acta Chimica Sinica ›› 1982, Vol. 40 ›› Issue (3): 257-266. Previous Articles     Next Articles

在Lewis酸催化下N-苯乙基甘氨酸衍生物的分子内环化反应研究及苯并-3-氮杂环庚酮-1衍生物的合成

廖增琨, 李纪生, 奚士康, 宋爱腾, 吉改姣, 黄志镗   

  1. 中国科学院化学研究所 北京
  • 投稿日期:1980-07-19 发布日期:2013-06-03
  • 通讯作者: 廖增琨

INTRAMOLECULAR CONDENSATION OF SOME N-HOMOPIPERONYLGLYCINE DERIVATIVES UNDER THE CATALYSIS OF SOME LEWIS ACIDS AND THE SYNTHESIS OF 7, 8-METHYLENEDIOXY-1, 2, 4, 5-TETRAHYDROBENZAZEPIN-3-ONE-1 DERIVATIVES

LIAO ZENG-KUN, LI JI-SHENG, XI SHI-KANG, SONG AI-TENG, JI GAI-JIAO, HUANG ZHI-TANG   

  1. Institute of Chemistry, Academia Sinica, Beijing
  • Received:1980-07-19 Published:2013-06-03

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The intramolecular oyclization of some N-piperonylglycine derivatives under the catalysis of Lewis acids was studied.In example 3a, in which the nitrogen atom was not protected, under the aotion of(CF3C0)2O-CF3COOH, 3a was converted into 3c, 3-othyl-8, 9-methylenedioxy-10b-trifluoromethyl-2, 3, 5, 6-tetrahydro-10b H-oxazolo(2, 3-a)-isoquinoline, instead of 3b. The structure of 3c was identified through IR, 13CNMR and also through the identification of its hydrolytic product Sd and the methyl ester 3e.