Acta Chimica Sinica ›› 1981, Vol. 39 ›› Issue (3): 237-242. Previous Articles     Next Articles

青木香的有效成分研究——Ⅱ.7-羟基马兜铃酸-A和7-甲氧基马兜铃酸-A

陈仲良, 黄宝山, 朱大元, 殷梦龙   

  1. 中国科学院上海药物研究所
  • 投稿日期:1979-03-22 发布日期:2013-06-03

STUDIES ON THE ACTIVE PRINCIPLES OF ARISTOLOCHIA DEBILIS Ⅱ. 7-HYDROXY ARISTOLOCHIC ABID-A AND 7-METHOXY ARISTOLOCHIC ACID-A

CHEN ZHONG-LIANG, HUANG BAO-SHAN, ZHU DA-YUAN, YIN MENG-LONG   

  1. Shanghai Institute of Materia Medica, Academia Sinica
  • Received:1979-03-22 Published:2013-06-03

Among the Chinese drugs, the Ariatolochia species such as A. howfi belong to an important genus of Aristolochiaceae. It is used in the treatment of some bacteria and virus infections in Hainan, but does not inhibit bacterial in vitro Aristolochic acid, the active principle of European species (A. clematitis) possesses phagocyte stimulating action and has been used clinically. In this paper, we separated and purified the acid fraction of Ching-Mu-Xiang (A. debilis) and study its clinical effect, Four crystalline substances have been isolated, Among them two wero identified as aristolochic acid-A (1) and C (2a).The other two compounds are new nitrophenanthrenic acids, and their structures are established as 7-hydroxy aristolochic acid-A (3) and 7-methoxy aristolochic acid-A (4), respectively.