Seven alkaloids were isolated.from the roots of Zanthozylrum nitidum ((Rogb.) DC and sig of them were identified as nitidine chloride (1),oxynitidine (2),dihydronitidine (8),6-methoay-6,6-d.ihydrochelerythrine (4),α-allocsryptopine (5) and skimmianine(6).The structural study on 7 is in progress.1 and 4 were able to increase the life span of mice inoculated with Ehrlioh's ascites tumor,while 2,8,5 and 6 were inactive.1 was effective in the treatment of chronic myelocytio leukemia.