Acta Chimica Sinica ›› 1978, Vol. 36 ›› Issue (3): 221-228. Previous Articles     Next Articles

甲基丙二酸衍生物的Knoevenagel反应

袁开基, 葛为公   

  1. 上海第一医学院药学系有机化学教研组
  • 投稿日期:1978-02-20 发布日期:2013-06-03

THE KNOEVENAGEL REACTION OF METHYLMALONIC ACID AND ITS DERIVATIVES

YUAN KAI-CHI, KO WEI-KUNG   

  1. Department of Organic Chemistry, School of Pharmacy, Shanghai First Medical College
  • Received:1978-02-20 Published:2013-06-03

The Gensler and the Fujiwara processes for the Knoevenagel reaction of methylma-lonio acid and derivatives with aromatic aldehydes have been reinvestigated. The Gensler process has a wider range of application than the Fnjiwara prooeas and the yields are higher too. The cause is attributed to difference in mechanisms. It is believed that the Gender process involves the Knoevenagel or Rodionov mechanism whereas the Lapworth mechanism works with the Fujiwara process. The Gender process requires at least one free carbonyl group on the methylmalonio acid part and even so, it still does not react with α-cyanopropionio acid. Sterio factors are believed to be the cause.