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Acta Chimica Sinica ›› 1976, Vol. 34 ›› Issue (2): 123-128. Previous Articles     Next Articles

平喘药物的研究——Ⅰ.若干有平喘作用的4-氧-4氢-1-苯并吡喃-3-甲醛及反式-3-(4’-氧-4’氢-1’-苯并吡喃-3’基)丙烯酸的合成

顾坤健, 奚国良, 郭秀月, 唐才芳, 张鸿良   

  1. 上海药物研究所
  • 投稿日期:1976-03-13 发布日期:2013-06-03

STUDIES ON ANTIASTHMATIC AGENTS——Ⅰ.SYNTHESES OF SOME ANTIASTHMATIC 4-OXO-4H-1-BENZOPYRAN-3-CARBOXALDEHYDES AND TRANSM-3-(4’-OXO-4’H-1’-BENZOPYRAN-3’)ACRYLIC ACIDS

KU KUEN-CHIEN, HSI KUO-LIANG, KOH SHIU-YU, TANG TSAI-FANG, CHANG HUNG-LIANG   

  1. Shanghai Institute of Materia Medica
  • Received:1976-03-13 Published:2013-06-03

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A series of 4-ogo-4H-1-benzopyran-3-oarbogaldehydes and trans-3-4-oxo-4'H-1'-benzopyran-3')acrylic acids were synthsized and evaluated for antiasthmatic activity.Three of these compounds(Ⅸa,Ⅸd and Ⅸi)showed significant antiasthmatic activity in guinea,pigs induced by histamine and acetylcholine.Ⅸa has been subjected to clinical trials and proved to be effective in the treatment of certain types of asthma and bronchitis.