Acta Chimica Sinica ›› 1975, Vol. 33 ›› Issue (1): 57-60. Previous Articles     Next Articles

华中五味子的研究 Ⅰ.有效成分五味子酯甲的分离与结构

方圣鼎, 黄梅芬, 刘嘉森, 商耀良, 徐任生   

  1. 上海药物研究所
  • 投稿日期:1974-06-20 发布日期:2013-06-03

STUDIES ON THE CONSTITUENTS OF HUA-ZHONG-WU-WEI-ZI (SCHISANDRA SPHENANTHERA REHD ET WILS)Ⅰ. THE ISOLATION AND STRUCTURE OF SCHISANTHERIN A.

FANG SHENG-DIN, HUANG MEI-FEN, LIU JIA-SEN, OAO YAO-LIANG, HSU JEN-SHENG   

  1. Shanghai Institute of Materia Medica
  • Received:1974-06-20 Published:2013-06-03

A new lignan, named schisantherin A, has been isolated from the fruits of Hua-Zhong-Wu-Wei-Zi(Schisarndra sphenanthera Rehd et Wils) (Magnoliaceae).According to the pharmacological and preliminary clinical findings, the schisantherin A is one of the antihepatotoxic principle of this plant.It is a lignan unknown so far.The molecular formula of schisantherin A is found to be C30H32O9 by mass spectroscopit and elementary analyses.When treated with 10% potassium hydroxide in methanol, it was converted into the corresponding hydroxy compound, schisantherinol A (C23H28O8) and benzoic acid in high yields.By taking advantage of UV, IR,NMR and mess spectroscopy, the structures of the two compounds, schisantherin A and schisantherinol A, are shown to be Ⅰa and Ⅰb respectively.Finally, the structure including the positions of all of the functional groups and conformation of sohisantherin A is established by double resonance experiments and measurements of intramolecular nuclear Overhauser effects (NOE).The resints are shown in Ⅱ.