Acta Chimica Sinica ›› 1975, Vol. 33 ›› Issue (1): 75-78. Previous Articles     Next Articles

脱氧三尖杉酯碱及其类似物的研究

李述文, 戴金媛   

  1. 上海药物研究所
  • 投稿日期:1974-08-16 发布日期:2013-06-03

A STUDY ON THE DEOXYHARRINGTONINE AND ITS ANALOGUES

LI SHU-WEN, DAI JIN-YUAN   

  1. Shanghai Institute of Materia Medica
  • Received:1974-08-16 Published:2013-06-03

Deoxyharringtonine (Ⅰ) isolated from Cephalotazzcs plant material is known as an alkaloid with significant inhibitory activity against P-388 leukemia.We now report the synthesis of deoxyharringtonine (Ⅰ) by condensation of a-ketoacid (Ⅳ) with cephalotaxine (Ⅴ) through a Reformatsky reaction.The analogues (Ⅱ,Ⅲ)of deoxyharringtonine (Ⅰ) have been synthesized by the same procedure.