Acta Chimica Sinica ›› 1965, Vol. 31 ›› Issue (5): 406-412. Previous Articles     Next Articles

Ⅷ.O-乙基N, N-二乙氨基一(或二)硫代磷酸钠的制备及其化学反应

楊石先1,2, 陈天池1,2, 王琴孙1,2, 金桂玉1,2, 邵瑞鏈1,2, 刘綸祖1,2   

  1. 1. 南开大学元素有机化学研究所;
    2. 南开大学化学系
  • 投稿日期:1964-10-06 发布日期:2013-06-03

Ⅷ. THE PREPARATIONS AND CHEMICAL REACTIONS OF SODIUM SALTS OF O-ETHYL N, N-DIETHYL-PHOSPHOROAMIDO-MONO (OR DI) THIOACIDS

YANG SHIH-HsIEN1,2, CHEN TIEN-CHIH1,2, WANG CHIN-SuN1,2, CHIN KUEI-YU1,2, SHAW ZUI-LIEN1,2, LIU LUN-TSU1,2   

  1. Institute of Element-Organic Chemistry and Department of Chemistry, Nankai University
  • Received:1964-10-06 Published:2013-06-03

The preparations and chemical properties of the sodium salts of O-ethyl N,N-diethyl-phosphoroamido-mono(or di)-thioacids (Ⅰ and Ⅱ) were reported. Ⅰ or Ⅱ reacted with alkyl halides to give the corresponding alkyl esters (Ⅴ, Ⅵ). By acidifying with diluted hydrochloric acid, Ⅰ and Ⅱ were converted into their corres-ponding acids (Ⅶ, Ⅷ) which, on treatment with alkyl iodide in the presence of or-ganic bases, diazomethane and cyclohexylamine, were transformed into the corresponding alkyl esters (Ⅸ),methyl ester (Ⅹ) and amide salts (ⅩⅠ) respectively. Reaction of Ⅱ with bromine or iodine gave the disulfide (ⅩⅡ),which was transformed into the phosphoro-amidothionochloridate (Ⅲ) by reacting with chlorine.