Acta Chimica Sinica ›› 1956, Vol. 22 ›› Issue (6): 472-477. Previous Articles     Next Articles

α, ω-双-(对-氨基苯氧基)-烷类的合成

杨庆生, 瞿德浩, 张其楷   

  1. 医学科学院
  • 投稿日期:1956-08-20 发布日期:2013-06-03

SYNTHESIS OF α, ω-BIS-(p-AMINOPHENOXY)-ALKANES

YANG CHING-SEN, CHÜ TE-HAO, CHANG CHI-CHIEK   

  1. Institute of Medical Sciences
  • Received:1956-08-20 Published:2013-06-03

α,ω-Bis-(p-aminophenoxy)-pentane and heptane have been prepared by the condensation of p-nitrophenol with the corresponding α,ω-dibromo-alkanes, and then by reduction respectively, while α,ω-bis-(p-methylaminophenoxy)-pentane and heptane have been condensed similarly, but using p-(N-p-toluenesulfonyl-N-methylamino)-phenol or p-(N-acetyl-N-methylamino)-phenol instead of p-nitrophenol, followed by hydrolysis. These compounds are to be tested for the activity against Schistosomiasis Japonica in experimentally infected animals.