Acta Chimica Sinica ›› 1956, Vol. 22 ›› Issue (5): 335-342. Previous Articles     Next Articles

喹唑啉类杂环化合物的化学——Ⅰ.喹唑酮的氯化反应

蒋明谦, 李钧, 李仁利   

  1. 北京医学院药学系
  • 投稿日期:1956-05-16 发布日期:2013-06-04

CHEMISTRY OF THE QUINAZOLINE SERIES——Ⅰ.CHLORINATION OF QUINAZOLONE-4

CHIANG MING-CHIEN(M. C. CHIANG), LI CHUN, LI JEN-LI   

  1. Department of Pharmacy, Peking Medical College
  • Received:1956-05-16 Published:2013-06-04

Quinazolone-4 was chlorinated with chlorine in glacial acetic acid,with ferric chloride as catalyst.The reaction was carried out at different temperatures (39-100Å),and with different amount of chlorine (molar ratio of chlorine to quinazolone varying from 0.92 to 1.81).The chlorinated products were separated and purified by recrystallization from benzene,ethanol,aqueous ethanol,butanol and acetone,and were found to be 6-chloroquinazolone (m.p.268-269Å),8-chloroquinazolone (m.p.300-302Å)and 6,8 dichloroquinazolone (m.p.347-349Å) respectively.Their identities were established by elementary analysis and mixed melting point tests with known synthetic compounds.