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Acta Chimica Sinica ›› 1956, Vol. 22 ›› Issue (5): 379-385. Previous Articles Next Articles
文广伶, 董永明, 宋鸿锵, 张其楷
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WEN KUANG-LING, TUNG YEONG-MING, SOONG HONG-TSIANG, CHANG CHI-CHIEK
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Two series of piperazines,alkyl 1-methyl-piperazine-4-dithiocarbamate citrates and 1-methyl-4-aryl-thiocarbamyl-piperazine citrates have been- prepared for testing their therapeutic effect in the treatment of Schistosomiasis Japonica.The starting material used for these two series was 1-methyl-piperazine,prepared from piperazine by means of partial reductive methylation.By the interaction of I-methyl-piperazine with sodium ethoxide and carbon disulfide,we obtained sodium 1-methyl-piperazine-4-dithiocarbamate.This sodium salt reacted with alkyl halides to form alkyl I-methyl-piperazine-4-dithiocarbamates.1-Methyl-4-aryl-thiocarbamyl-piperazines were prepared from 1-methyl-piperazine and the ap-propriateenyl isothiocyanates in ether solution.
WEN KUANG-LING, TUNG YEONG-MING, SOONG HONG-TSIANG, CHANG CHI-CHIEK. PIPERAZINES Ⅰ.SYNTHESES OF ALKYL 1-METHYL-PIPERAZINE-4-DITHIOCARBAMATE CITRATES AND 1-METHYL-4-ARYL-THIOCARBAMYL-PIPERAZINE CITRATES[J]. Acta Chimica Sinica, 1956, 22(5): 379-385.
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