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Acta Chimica Sinica ›› 1955, Vol. 21 ›› Issue (4): 385-400. Previous Articles     Next Articles

嘧啶的研究:氯对硫醇嘧啶的作用2-酮-4-氨基-5,6-二甲基-1,2-二氢-嘧啶的合成

纪育澧, 凌育宸   

  1. 中央卫生研究院药物学系
  • 投稿日期:1955-05-20 发布日期:2013-06-04

PYRIMIDINE RESEARCH.THE ACTION OF CHLORINE ON MERCAPTOPYRIMIDINES.SYNTHESIS OF 4, 5-DIMETHYL-CYTOSINE

CHI YUOH-FONG, LING YUOH-CHERN   

  1. The Department of Therapeutics, Central Institute of Health
  • Received:1955-05-20 Published:2013-06-04

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The condensation of thiourea with ethyl methyl-acetoacetate in the presence of sodium ethylate in absolute ethyl alcohol gives 2-thio-4,5-dimethyl-6-oxy-pyrimidine,m.p.279-280°,which is ethylated to form 2-ethylmercapto-4,5-dimethyl-6-oxy-pyrimidine,m.p.155-156° by treating the former with ethyl iodide in the presence of sodium ethylate in absolute alcohol.