4-Methyl-2,6-dichloropyrimidine was prepared by heating 4-methyl-uracil with phosphorous osychloride in the presence of phosphorous pentachloride; and it boiled at 97° at 7 mm, at 102° at 10 mm, or at 113° at 13 mm. 4-Methyl-2,6-dichloropyrimidine reacted with sodium methoxide in anhydrous methyl alcohol, forming 4-methyl-2,5-dimethosy-pyrimidine, which was isolated by ether extraction and purified by vacuum distillation.