Acta Chimica Sinica ›› 2004, Vol. 62 ›› Issue (8): 839-841. Previous Articles     Next Articles

抗HIV活性海洋天然产物Didemnaketals的合成研究——C1~C7片段的合成

李学强1,2, 王洪1, 涂永强1, 王少华1   

  1. 1. 兰州大学化学化工学院, 功能有机分子化学国家重点实验室, 兰州, 730000;
    2. 宁夏大学化学化工学院, 银川, 750021
  • 投稿日期:2003-10-20 修回日期:2003-12-26 发布日期:2014-02-18
  • 通讯作者: 涂永强,E-mail:tuyq@lzu.edu.cn E-mail:tuyq@lzu.edu.cn
  • 基金资助:
    国家自然科学基金(Nos.30271488,20021001,203900501)资助项目.

Synthetic Studies of the HIV-Inhibitive Marine Natural Products --Synthesis of the C1~C7 Fragment of Didemnaketal A

LI Xue-Qiang1,2, WANG Hong1, TU Yong-Qiang1, WANG Shao-Hua1   

  1. 1. Department of Chemistry and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000;
    2. Department of Chemistry, Ningxia University, Yinchuan 750021
  • Received:2003-10-20 Revised:2003-12-26 Published:2014-02-18

The stereoselective synthesis of the C1~C7 fragment (3R,4S,6R)-3,4-di[(tert-butyl dimethylsilyl)-oxy]-7-hydroxy-6-methylheptan-2-one, which is the crucial intermediate for synthesis of the HIV-1 protease inhibitive didemnaketals, was achieved from the natural (+)-pulegone via a series of the intramolecular chiral induction.

Key words: Didemnaketal A, stereoselective synthesis, intramolecular chiral induction

CLC Number: