Study of the Binding Mode of a Chromophoric Host Zinc Protoporphyrin with Histamine

Acta Chimica Sinica ›› 2004, Vol. 62 ›› Issue (9): 905-910. Previous Articles Next Articles

吸光分子识别功能试剂锌原卟啉与组胺的结合模式研究

童爱军¹, 童春媛¹, 杨庆怡¹, 加藤雄一², 西泽精一², 寺前纪夫²

1. 清华大学化学系,北京,100084;
2. 日本东北大学化学系,日本仙台980-8578

投稿日期:2003-08-28 修回日期:2004-01-12 发布日期:2014-02-17
通讯作者: 童爱军,E-mail:tongaj@chem.tsinghua.edu.cn E-mail:tongaj@chem.tsinghua.edu.cn
基金资助:
国家自然科学基金(No.20375021)和国家自然科学基金国际合作(No.20311140203)资助项目.

Study of the Binding Mode of a Chromophoric Host Zinc Protoporphyrin with Histamine

TONG Ai-Jun¹, TONG Chun-Yuan¹, YANG Qing-Yi¹, Kato Yuichi², Nishizawa Seiichi², Teramae Norio²

1. Department of Chemistry, Tsinghua University, Beijing 100084;
2. Department of Chemistry, Tohoku University, Sendai, Japan 980-8578

Received:2003-08-28 Revised:2004-01-12 Published:2014-02-17

Abstract

Molecular recognition of histamine by Zn(Ⅱ)-protoporphyrin (ZnPP) in water was investigated by using UV-Vis titration.An NOE mode of ¹H NMR was used to study the host guest binding in DMSO-d₆ solution.Changes of proton chemical shifts for both ZnPP and histamine before and after complexing and a computer aided structure simulation confirmed our suggested binding mode that two hydrogen bonds between amino group of histamine and the two carboxylic acid groups of ZnPP as well as coordination of zinc to imidazole contribute to the binding.

Key words: Zn(Ⅱ)-protoporphyrin, histamine, UV-Vis, ¹H NMR, molecular orbit model

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TONG Ai-Jun, TONG Chun-Yuan, YANG Qing-Yi, Kato Yuichi, Nishizawa Seiichi, Teramae Norio. Study of the Binding Mode of a Chromophoric Host Zinc Protoporphyrin with Histamine[J]. Acta Chimica Sinica, 2004, 62(9): 905-910.

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吸光分子识别功能试剂锌原卟啉与组胺的结合模式研究

Study of the Binding Mode of a Chromophoric Host Zinc Protoporphyrin with Histamine

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