Acta Chimica Sinica ›› 2004, Vol. 62 ›› Issue (16): 1565-1568. Previous Articles     Next Articles

几种新的外消旋过渡金属簇合物在纤维素衍生的高效液相色谱手性固定相上的直接拆分

李文智1,2, 张伟强1, 李永民1, 窦建民2, 殷元骐1, 陈立仁1   

  1. 1. 中国科学院兰州化学物理研究所, 兰州, 730000;
    2. 聊城大学化学化工学院, 聊城, 252059
  • 投稿日期:2003-08-11 修回日期:2004-04-20 发布日期:2014-02-17
  • 通讯作者: chenlr@ns.lzb.ac.cn
  • 作者简介:陈立仁E-mail:chenlr@ns.lzb.ac.cn;tel:0931-8278931;Fax:0931-8277088.
  • 基金资助:
    中国科学院重点基金(No.KY95-S1-205)和中国科学院‘百人计划'资助项目.

Enantioseparation of Novel Chiral Tetrahedrane-Type Clusters on a Cellulose Tris(3,5-dimethylphenylcarbamate) Chiral Stationary Phase by HPLC

LI Wen-Zhi1,2, ZHANG Wei-Qiang1, LI Yong-Min1, DOU Jian-Min2, YIN Yuan-Qi1, CHEN Li-Ren1   

  1. 1. Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000;
    2. Department of Chemistry, Liaocheng University, Liaocheng 252059
  • Received:2003-08-11 Revised:2004-04-20 Published:2014-02-17

s Direct enantiomeric resolution of five novel chiral tetrahedrane-type clusters has firstly been achieved on cellulose tris(3,5-dimethylphenylcarbamate) chiral stationary phase, using hexane as the mobile phase with various alcohols as modifiers.The influence of the mobile phase composition on the enantioselectivity was discussed, and the effect of structural variation of the solutes on their enantioseparation was also investigated and compared.It was found that both the metal in the tetrahedral core and the ligand coordinated to the atom in tetrahedral core had significant effects on their chromatographic behaviors.

Key words: cellulose tris(3,5-dimethylphenylcarbamate), chiral transition metal tetrahedral cluster, enantioseparation