Advances in Ru(II)-based Photoactivated Chemotherapy Agents

doi:10.6023/A16090470

Acta Chim. Sinica ›› 2017, Vol. 75 ›› Issue (1): 49-59.DOI: 10.6023/A16090470 Previous Articles Next Articles

Special Issue: 有机光化学

Review

钌(II)光活化化疗试剂研究进展

周前雄, 王雪松

中国科学院理化技术研究所光化学转换与功能材料重点实验室北京 100190

投稿日期:2016-09-05 修回日期:2016-10-09 发布日期:2016-10-10
通讯作者: 周前雄,E-mail:zhouqianxiong@mail.ipc.ac.cn;王雪松,E-mail:xswang@mail.ipc.ac.cn E-mail:zhouqianxiong@mail.ipc.ac.cn;xswang@mail.ipc.ac.cn
作者简介:周前雄,2010年于中国科学院理化技术研究所获得博士学位并留所工作,目前任副研究员,主要从事金属配合物光动力抗肿瘤以及光动力抗菌方面的研究;王雪松,中国科学院理化技术研究所研究员、博士生导师.主要从事药物及药物中间体的光化学合成以及光疗药物设计合成及其机理研究.
基金资助:
项目受国家自然科学基金（Grant Nos.21273259，21571181）资助.

Advances in Ru(II)-based Photoactivated Chemotherapy Agents

Zhou Qianxiong, Wang Xuesong

Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190

Received:2016-09-05 Revised:2016-10-09 Published:2016-10-10
Supported by:
Project supported by the National Natural Science Foundation of China (Grant Nos. 21273259, 21571181).

Many Ru(II) complexes can undergo photoinduced ligand dissociation in aqueous solutions, and the formed aqua Ru(II) species may bind to DNA covalently. This property has been applied to develop novel photoactivated chemotherapy (PACT) agents for cancer treatment in recent years. By finely tuning ligand structures and coordination configurations, PACT may realize highly selective and on-demand release of active species in cancer tissues, leading to an improved efficacy and diminished side effects. In this review, the progress in Ru(II)-based PACT agents was fully discussed and a perspective for their future development was included.

Key words: chemical therapy, photoactivation, Ru(II) complexes, ligand dissociation

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Zhou Qianxiong, Wang Xuesong. Advances in Ru(II)-based Photoactivated Chemotherapy Agents[J]. Acta Chim. Sinica, 2017, 75(1): 49-59.

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钌(II)光活化化疗试剂研究进展

Advances in Ru(II)-based Photoactivated Chemotherapy Agents

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