Acta Chim. Sinica ›› 2017, Vol. 75 ›› Issue (11): 1036-1046.DOI: 10.6023/A17060289 Previous Articles     Next Articles

Special Issue: 纳米传感分析

Review

纳米等离子体生物传感及成像

苏莹莹a,b, 彭天欢b, 邢菲菲a, 李迪b, 樊春海b   

  1. a 上海大学理学院化学系 上海 200444;
    b 中国科学院上海应用物理研究所 物理生物学研究室 上海 201800
  • 投稿日期:2017-06-30 发布日期:2017-09-06
  • 通讯作者: 樊春海, 李迪 E-mail:fchh@sinap.ac.cn;lidi@sinap.ac.cn
  • 作者简介:苏莹莹,1991年出生于河南开封,2015年在河南师范大学获得理学学士学位,主要研究方向为单分子催化;彭天欢,1988年出生于湖南益阳,主要研究方向为贵金属等离子体纳米材料在传感、成像及催化领域的应用研究;邢菲菲,1978年出生于黑龙江望奎县,1999年7月于黑龙江大学化学化工学院获得理学学士学位,2006年3月于中国科学院长春应用化学研究所稀土资源综合利用国家重点实验室获得理学博士学位(硕博连读);李迪,2000年获大连理工大学学士学位.主要从事电分析化学与生物传感交叉学科,包括发展新型电化学生物传感、纳米(金属纳米材料,量子点等)生物传感方法,DNA分子机器在生物传感领域的应用等方面;樊春海,南京大学生物化学学士(1996年)、博士(2000年),加州大学圣巴巴拉分校(UCSB)有机固体研究所和加州纳米系统研究所博士后.
  • 基金资助:

    项目受国家重点基础研究发展计划(Nos.2013CB932803,2013CB933800)、国家重点研发计划(Nos.2016YFA0201200,2016YFA0400900)及国家自然科学基金委(Nos.21675166,21227804)资助.

Nanoplasmonic Biological Sensing and Imaging

Su Yingyinga,b, Peng Tianhuanb, Xing Feifeia, Li Dib, Fan Chunhaib   

  1. a Department of Chemistry, College of Science, Shanghai University, Shanghai 200444;
    b Division of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800
  • Received:2017-06-30 Published:2017-09-06
  • Contact: 10.6023/A17060289 E-mail:fchh@sinap.ac.cn;lidi@sinap.ac.cn
  • Supported by:

    Project supported by the National Basic Research Program of China (Nos. 2013CB932803, 2013CB933800), the National Key R&D Program of China (Nos. 2016YFA0201200, 2016YFA0400900) and the National Natural Science Foundation of China (Nos. 21675166, 21227804).

The localized surface plasmon resonance of metal nanoparticles is the collective oscillation of electrons on particle surface. The localized electromagnetic interaction brings a series of novel functions and applications. Plasmonic nanomaterials have been the significant part of nanophotonics, since its' localized surface plasmon resonance (LSPR) can focus incident phonons on the nanoscale surface. The unique plasmonic property is highly sensitive to their size, shape, coupling between particles as well as local dielectric environment. These properties can be utilized for the development of new biosensing and bioimaging applications. To date, many LSPR sensing strategies have been developed with outstanding measurement capabilities, enabling detection down to the single-molecule level, including LSPR-based sensing, surface-enhanced Raman scattering, metal-enhanced fluorescence, dark-field light-scattering, metal-mediated fluorescence resonance energy transfer. Moreover, the unique optical stability of plasmonic nanoparticles enables them as ideal probes in cellular imaging. Here, recent examples on application of plasmonic nanostructures in sensing and bioimaging are summarized, and perspectives are provided as well.

Key words: nanophotonics, noble metal nanomaterial, localized surface plasmon resonance (LSPR), sensing, bioimaging