Advances in Nucleic Acid Drug Delivery Systems for Liver Cancer Treatment

doi:10.6023/A24090258

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用于肝癌治疗的核酸药物递送体系研究进展

刘婉婉^a#, 李丹^a#, 邓可欣^a, 刘君禹^a, 张吉松^c, 张灿阳^a,b,d,e*

^a清华大学深圳国际研究生院广东深圳 518055;
^b工业生物催化教育部重点实验室（清华大学）北京 100084;
^c清华大学化学工程系北京 100084;
^d活性蛋白多肽绿色生物制造广东普通高校重点实验室(清华大学深圳国际研究生院);
^e深圳湾实验室广东深圳 518067

作者简介:刘婉婉,就读于清华大学深圳国际研究生院,2021级材料与化工专业硕士。主要研究方向为核酸药物递送体系开发与肿瘤治疗。李丹,就读于清华大学深圳国际研究生院,2022级材料与化工专业硕士。主要研究方向为有机-无机杂合生物载体材料制备及肿瘤治疗。邓可欣,就读于清华大学深圳国际研究生院,2021级材料与化工专业硕士。主要研究方向为治疗性肿瘤疫苗的开发与评价。刘君禹,就读于清华大学深圳国际研究生院,化学工程与技术专业博士。主要研究方向为口服递送系统设计、天然产物体内外功效及机制研究、生物信息学分析等。张吉松,2014年博士毕业于清华大学化学工程专业,现任清华大学化学工程系副教授。目前从事流动化学和微填充床气液固反应研究,主要包括：1）基于微填充床技术的加氢和氧化反应;2）医药中间体的连续高效合成;3）基于微器件的在线表征和分析技术。张灿阳,2014年博士毕业于华南理工大学化学工程专业,现任清华大学深圳国际研究生院副教授、博士生导师。研究方向面向生物医药与生命健康领域重大需求与关键问题,聚焦生命物质与非生物元件互作与适配及规模化制备研究,基于靶向递送技术,理性设计和开发工程化的活性物质生物杂合体系,实现功能调控与性能超越,优化多种重大疾病的治疗,如癌症、感染、自身免疫性疾病。
基金资助:
广东省珠江人才计划（项目编号：2021QN02Y225）,清华大学深圳国际研究生院海外科研合作基金（项目编号：HW2023009）和化工系-iBHE专项合作联合基金资助

Advances in Nucleic Acid Drug Delivery Systems for Liver Cancer Treatment

LIU Wanwan^a#, LI Dan^a#, DENG Kexin^a, LIU Junyu^a, ZHANG Jisong^c, ZHANG Can Yang^a,b,d,e*

^aShenzhen International Graduate School, Tsinghua University, Shenzhen 518055, Guangdong, China;
^bKey Laboratory of Industrial Biocatalysis, Ministry of Education; Tsinghua University, Beijing 100084, China;
^cDepartment of Chemical Engineering, Tsinghua University, Beijing 100084, China;
^dKey Laboratory of Active Proteins and Peptides Green Biomanufacturing of Guangdong Higher Education Institutes,Tsinghua Shenzhen International Graduate School;
^eShenzhen Bay Laboratory, Shenzhen 518055, Guangdong, China

Contact: * E-mail: zhang.cy@sz.tsinghua.edu.cn; xhxing@mail.tsinghua.edu.cn.
About author:^#Liu W and Li D contributed equally to this work.
Supported by:
Pearl River Talent Project (Grant No. 2021QN02Y225), Overseas Research Cooperation Fund of Shenzhen International Graduate School, Tsinghua University (Grant No. HW2023009) and Department of Chemical Engineering-iBHE Cooperation Joint Fund Project.

Liver cancer has become a major threat to human health due to its high lethality, poor prognosis and strong drug resistance. With the in-depth researches on liver cancer and the development of nucleic acid biotechnology, nucleic acid drugs have gradually shown great potential in liver cancer treatment. Compared with traditional therapeutic drugs like chemical drugs, nucleic acid drugs have the characteristics of strong specificity, rich potential targets, relatively short development cycle, and negligible toxic side effects, etc. However, due to the poor stability of nucleic acid molecules, it is difficult to achieve long circulation time in body, high internalization activity, and lysosomal escape capacity in cell, which leads to the low transfection efficiency and prevents it from exerting the therapeutic effect. Therefore, it’s of great importance to develop drug delivery systems for nucleic acid drugs to improve the therapeutic effect and enhance the stability as well as the targeting of nucleic acid drugs in vivo. Currently, the delivery vectors for nucleic acid drugs include viral vectors and non-viral vectors. Viral vectors, including adenovirus, lentivirus, etc., have the advantages of high transfection efficiency and high specificity, but their application prospect is greatly restricted due to the safety and ethical issues. Non-viral vectors are safer, more stable and structurally tunable compared with viral vectors. Non-viral vectors, including covalently attached systems, inorganic nanoparticles, lipid nanoparticles (LNP), polymer nanoparticles (PNP), DNA nanoparticles etc., have high application prospects due to their rich types, diverse and adjustable structures, and good biocompatibility. In this paper, we systematically summarize the current nucleic acid drug delivery systems, especially for liver cancer, and carefully classify the application scenarios and characteristics of the current delivery systems and introduce all the delivery systems as exhaustively as possible. It provides reference for the research and development of innovative nucleic acid drug delivery systems tailored for liver cancer. Collectively, we think that drug delivery systems for nucleic acid drugs could be potential in clinic to promote the improvement of liver cancer therapy.

Key words: liver cancer, gene delivery, nucleic acid drugs, gene therapy, non-viral vectors

Cite this article

LIU Wanwan, LI Dan, DENG Kexin, LIU Junyu, ZHANG Jisong, ZHANG Can Yang. Advances in Nucleic Acid Drug Delivery Systems for Liver Cancer Treatment[J]. Acta Chimica Sinica, doi: 10.6023/A24090258.

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References

[1] Llovet J. M.; Kelley R. K.; Villanueva A.; Singal A. G.; Pikarsky E.; Roayaie S.; Lencioni R.; Koike K.; Zucman-Rossi J.; Finn, R. S. Nat Rev Dis Primers,2021, 7, 1.
[2] Zheng R.; Qu C.; Zhang S.; Zeng H.; Sun K.; Gu X.; Xia C.; Yang Z.; Li H.; Wei W.; Chen W.; He, J. Chin J Cancer Res,2018, 30, 571.
[3] Craig A. J.; von Felden J.; Garcia-Lezana T.; Sarcognato S.; Villanueva, A. Nat Rev Gastroenterol Hepatol,2020, 17, 3.
[4] Yang C.; Zhang H.; Zhang L.; Zhu A. X.; Bernards R.; Qin W.; Wang, C. Nat Rev Gastroenterol Hepatol,2023, 20, 4.
[5] Dai Q.; Zhang C.; Yuan Z.; Sun Q.; Jiang, Y. Expert Opin Drug Discov,2020, 15, 243.
[6] Le Grazie M.; Biagini M. R.; Tarocchi M.; Polvani S.; Galli, A. World J Hepatol,2017, 9, 907.
[7] Cabral L. K. D.; Tiribelli C.; Sukowati, C. H. C. Cancers,2020, 12, 6.
[8] Fornari F.; Giovannini C.; Piscaglia F.; Gramantieri, L. J Hepatocell Carcino,2021, 8, 741.
[9] Singal A. G.; Kanwal F.; Llovet, J. M. Nat Rev Clin Oncol,2023, 20, 12.
[10] Galle P. R.; Dufour J.-F.; Peck-Radosavljevic M.; Trojan J.; Vogel A. Future Oncol,2021, 17, 1237.
[11] Zhang H.; Zhang W.; Jiang L.; Chen Y. Biomark Res,2022, 10, 3.
[12] Sonbol M. B.; Riaz I. B.; Naqvi S. A. A.; Almquist D. R.; Mina S.; Almasri J.; Shah S.; Almader-Douglas D.; Uson Junior, P. L. S.; Mahipal A.; Wee W.; Jin Z.; Mody K.; Starr J.; Borad M. J.; Ahn D. H.; Murad M. H.; Bekaii-Saab T. JAMA Oncol,2020, 6, e204930.
[13] Li J.; Wang Y.; Zhu Y.; Oupický, D. J Control Release,2013, 172, 589.
[14] Xu L.; Anchordoquy, T. J Pharm Sci,2011, 100, 38.
[15] Chakraborty E.; Sarkar D. Cancers,2022, 14, 11.
[16] Xu W.; He W.; Du Z.; Zhu L.; Huang K.; Lu Y.; Luo, Y. Angew. Chem. Int. Ed.,2021, 60, 6890.
[17] Raemdonck K.; Martens T. F.; Braeckmans K.; Demeester J.; De Smedt, S. C. Adv Drug Delivery Rev,2013, 65, 1123.
[18] Quemener A. M.; Bachelot L.; Forestier A.; Donnou-Fournet E.; Gilot D.; Galibert M.-D. WIREs RNA,2020, 11, e1594.
[19] Bajan S.; Hutvagner G. Cells,2020, 9, 1.
[20] Shang R.; Lee S.; Senavirathne G.; Lai, E. C. Nat Rev Genet,2023, 24, 12.
[21] Mirzaei S.; Mahabady M. K.; Zabolian A.; Abbaspour A.; Fallahzadeh P.; Noori M.; Hashemi F.; Hushmandi K.; Daneshi S.; Kumar A. P.; Aref A. R.; Samarghandian S.; Makvandi P.; Khan H.; Hamblin M. R.; Ashrafizadeh M.; Zarrabi A. Life Sci,2021, 275, 119368.
[22] Wang Y.; Xie Y.; Kilchrist K. V.; Li J.; Duvall C. L.; Oupický, D. ACS Appl. Mater. Interfaces,2020, 12, 4308.
[23] Chen,Y.; Xu,N.; Hu Z.-L. J Biol Eng2020, 36, 622 (in Chinese).
(陈毓, 许诺, 胡振林, 生物工程学报, 2020, 36, 622.)
[24] Zeng R.-X.; Chen P.Acta Chim. Sinica 2024, 82 53 (in Chinese).
(曾如馨, 陈鹏, 化学学报, 2024, 82, 53.)
[25] K. Sharma V.; Rungta P.; K. Prasad, A. RSC Adv,2014, 4, 16618.
[26] Lieberman, J. Nat Struct Mol Biol, 2018, 25, 5.
[27] Okumura K.; Nakase M.; Inui M.; Nakamura S.; Watanabe Y.; Tagawa, T. J Gene Med,2008, 10, 910.
[28] Jain S.; Venkataraman A.; Wechsler M. E.; Peppas, N. A. Adv Drug Delivery Rev,2021, 179, 114000.
[29] Paunovska K.; Loughrey D.; Dahlman, J. E. Nat Rev Genet,2022, 23, 5.
[30] Zeng Z.-X.; Wu J.-Y.; Wu J.-Y.; Li Y.-N.; Fu Y.-K.; Zhang Z.-B.; Liu D.-Y.; Li H.; Ou X.-Y.; Zhuang S.-W.; Yan M.-L. Hepatol Int,2023, 18, 651.
[31] Jia L.-T.; Chen S.-Y.; Yang, A.-G. Cancer Treat Rev,2012, 38, 868.
[32] Reed, J. C. Cancer Cell, 2003, 3, 17.
[33] Ghobrial I. M.; Witzig T. E.; Adjei, A. A. Nat Rev Drug Discov,2023, 22, 127.
[34] Karjoo Z.; Chen X.; Hatefi, A. Adv Drug Delivery Rev,2016, 99, 113.
[35] Duarte S.; Carle G.; Faneca H.; Lima, M. C. P. de; Pierrefite-Carle, V. Cancer Lett,2012, 324, 160.
[36] Anderson D. G.; Peng W.; Akinc A.; Hossain N.; Kohn A.; Padera R.; Langer R.; Sawicki J. A. PNAS,2004, 101, 16028.
[37] Yu X.; Wang T.; Li Y.; Li Y.; Bai B.; Fang J.; Han J.; Li S.; Xiu Z.; Liu Z.; Yang X.; Li Y.; Zhu G.; Jin N.; Shang C.; Li X.; Zhu Y. Cancer Med,2023, 12, 8306.
[38] Ma J.-L.; Han S.-X.; Zhao J.; Zhang D.; Wang L.; Li Y.-D.; Zhu, Q. Int J Oncol,2012, 41, 1013.
[39] Wang J.; Lu X.-X.; Chen D.-Z.; Li S.-F.; Zhang, L.-S. World J Gastroenterol,2004, 10, 400.
[40] Santo D.; Cordeiro R. A.; Mendonça P. V.; Serra A. C.; Coelho J. F. J.; Faneca H. Biomacromolecules,2023, 24, 1274.
[41] Reghupaty S. C.; Sarkar D. Cancers,2019, 11, 9.
[42] Iimuro Y.; Fujimoto, J. J Hepatobiliary Pancreat Surg,2003, 10, 45.
[43] Christou C.; Stylianou A.; Gkretsi V. Cells,2024, 13, 2.
[44] Younis M. A.; Khalil I. A.; Elewa Y. H. A.; Kon Y.; Harashima, H. J Control Release,2021, 331, 335.
[45] Hassin O.; Oren, M. Nat Rev Drug Discov,2023, 22, 2.
[46] Xiao Y.; Chen J.; Zhou H.; Zeng X.; Ruan Z.; Pu Z.; Jiang X.; Matsui A.; Zhu L.; Amoozgar Z.; Chen D. S.; Han X.; Duda D. G.; Shi J. Nat Commun,2022, 13, 1.
[47] Han R.; Wang Y.; Lu L. Pharmaceutics,2024, 16, 1.
[48] Zhou L.; Yi W.; Zhang Z.; Shan X.; Zhao Z.; Sun X.; Wang J.; Wang H.; Jiang H.; Zheng M.; Wang D.; Li, Y. Natl Sci Rev,2023, 10, nwad214.
[49] Ge N.-L.; Ye S.-L.; Zheng N.; Sun R.-X.; Liu Y.-K.; Tang Z.-Y.World J Gastroenterol, 2003, 9, 2182.
[50] Qian Y.; Chen Y.-Q.; Wu F.; Liu C.-X.; Hong T.-T.; Li W.; Chen, Y., Zhou, X. Chinese J. Chem2019, 37, 588 (in Chinese).
(倩瑶, 陈玉琪, 吴帆, 刘朝兴, 洪婷婷, 李伟, 陈毅, 周翔, 中国化学, 2019, 37, 588.)
[51] Wu,Q.; Tang,Y.-Y.; Yu,M.; Zhang,Y.-Y.; Li,X.M.Prog Chem 2020, 32 927 (in Chinese).
(吴晴, 唐一源, 余淼, 张悦莹, 李杏梅, 化学进展, 2020, 32, 927.)
[52] Giacca M.; Zacchigna, S. J Control Release,2012, 161, 377.
[53] Dicks M. D. J.; Spencer A. J.; Edwards N. J.; Wadell G.; Bojang K.; Gilbert S. C.; Hill A. V. S.; Cottingham, M. G. PLOS ONE,2012, 7, e40385.
[54] Mah C.; Byrne B. J.; Flotte, T. R. Clin Pharmacokinet,2002, 41, 901.
[55] Wilson, J. M. NEJM, 1996, 334, 1185.
[56] Reichenbach P.; Giordano Attianese, G. M. P.; Ouchen K.; Cribioli E.; Triboulet M.; Ash S.; Saillard M.; Vuillefroy de Silly R.; Coukos G.; Irving, M. Nat. Biomed. Eng,2023, 7, 9.
[57] Nayerossadat N.; Maedeh T.; Ali, P. A. Adv Biomed Res,2012, 1, 27.
[58] Crystal, R. G. Hum. Gene Ther, 2014, 25, 3.
[59] Benihoud K.; Yeh P.; Perricaudet, M. Curr Opin Biotech,1999, 10, 440.
[60] Wang Z.; Zhang X. Cytotherapy,2021, 23, 1045.
[61] Oudjedi A.; Allali A.; Bekli A.; Lounis M.; Ben Saad H.; Boukoufa M. Phys Sportsmed,2024, 52, 134.
[62] Barouch D. H.; Kik S. V.; Weverling G. J.; Dilan R.; King S. L.; Maxfield L. F.; Clark S.; Ng’ang’a D.; Brandariz K. L.; Abbink P.; Sinangil F.; de Bruyn G.; Gray G. E.; Roux S.; Bekker L.-G.; Dilraj A.; Kibuuka H.; Robb M. L.; Michael N. L.; Anzala O.; Amornkul P. N.; Gilmour J.; Hural J.; Buchbinder S. P.; Seaman M. S.; Dolin R.; Baden L. R.; Carville A.; Mansfield K. G.; Pau M. G.; Goudsmit J. Vaccine,2011, 29, 5203.
[63] Nat Biotechnol, 2022, 40, 5.
[64] Sung Y.; Kim S. Biomater,2019, 23, 8.
[65] Wahane A.; Waghmode A.; Kapphahn A.; Dhuri K.; Gupta A.; Bahal R. Molecules,2020, 25, 12.
[66] Ma Y.; Deng L.; Li S.-G.J Biol Eng 2022, 38, 2087 (in Chinese).
(马跃, 邓莉, 李善刚, 生物工程学报, 2022,38, 2087.)
[67] Foster D. J.; Brown C. R.; Shaikh S.; Trapp C.; Schlegel M. K.; Qian K.; Sehgal A.; Rajeev K. G.; Jadhav V.; Manoharan M.; Kuchimanchi S.; Maier M. A.; Milstein S. Mol Ther,2018, 26, 708.
[68] Kinberger G. A.; Prakash T. P.; Yu J.; Vasquez G.; Low A.; Chappell A.; Schmidt K.; Murray H. M.; Gaus H.; Swayze E. E.; Seth, P. P. Bioorg Med Chem Lett,2016, 26, 3690.
[69] Springer A. D.; Dowdy, S. F. Nucleic Acid Ther,2018, 28, 109.
[70] Rabiee N.; Ahmadi S.; Arab Z.; Bagherzadeh M.; Safarkhani M.; Nasseri B.; Rabiee M.; Tahriri M.; Webster T. J.; Tayebi, L. Int J Nanomed,2020, 15, 4237.
[71] Kurosaki T.; Higuchi N.; Kawakami S.; Higuchi Y.; Nakamura T.; Kitahara T.; Hashida M.; Sasaki H. Gene,2012, 491, 205.
[72] Wang S.; Reinhard S.; Li C.; Qian M.; Jiang H.; Du Y.; Lächelt U.; Lu W.; Wagner E.; Huang R. Mol Ther,2017, 25, 1556.
[73] Wan T.; Pan Q.; Liu C.; Guo J.; Li B.; Yan X.; Cheng Y.; Ping Y. Nano Lett.,2021, 21, 9761.
[74] Li C.; Si X.; Li J.-B. Acta Chim. Sinica 2023, 81, 1240 (in Chinese).
(李琛, 司笑, 李金波, 张艳, 化学学报, 2023, 81, 1240.)
[75] Uehara K.; Harumoto T.; Makino A.; Koda Y.; Iwano J.; Suzuki Y.; Tanigawa M.; Iwai H.; Asano K.; Kurihara K.; Hamaguchi A.; Kodaira H.; Atsumi T.; Yamada Y.; Tomizuka, K. Nucleic Acids Res,2022, 50, 4840.
[76] Son S. J.; Bai X.; Lee, S. B. Drug Discov Today,2007, 12, 650.
[77] Guo K.; Zhao X.; Dai X.; Zhao N.; Xu, F.-J. J Gene Med,2019, 21, e3084.
[78] Jun Loh X.; Lee T.-C.; Dou Q.; Roshan Deen, G. Biomater Sci,2016, 4, 70.
[79] Luther D. C.; Huang R.; Jeon T.; Zhang X.; Lee Y.-W.; Nagaraj H.; Rotello, V. M. Adv Drug Deliver Rev,2020, 156, 188.
[80] Rhim W.-K.; Kim J.-S.; Nam J.-M. Small,2008, 4, 1651.
[81] K.c R. B.; Thapa B.; Bhattarai N. Nanotechnol. Rev,2014, 3, 269.
[82] Guo S.; Huang Y.; Jiang Q.; Sun Y.; Deng L.; Liang Z.; Du Q.; Xing J.; Zhao Y.; Wang P. C.; Dong A.; Liang X.-J. ACS Nano,2010, 4, 5505.
[83] Mondal S.; Adhikari N.; Banerjee S.; Amin S. A.; Jha, T. Eur. J. Med. Chem,2020, 194, 112260.
[84] Yu S.; Wen R.; Wang H.; Zha Y.; Qiu L.; Li B.; Xue W.; Ma D. Chem. Mater.,2019, 31, 3992.
[85] Bharali D. J.; Klejbor I.; Stachowiak E. K.; Dutta P.; Roy I.; Kaur N.; Bergey E. J.; Prasad P. N.; Stachowiak M. K. PNAS,2005, 102, 11539.
[86] Csőgör Zs.; Nacken M.; Sameti M.; Lehr C.-M.; Schmidt, H. Mater. Sci. Eng. C,2003, 23, 93.
[87] Zhou Y.; Quan G.; Wu Q.; Zhang X.; Niu B.; Wu B.; Huang Y.; Pan X.; Wu, C. Acta Pharm Sin B,2018, 8, 165.
[88] Liu H.-J.; Luan X.; Feng H.-Y.; Dong X.; Yang S.-C.; Chen Z.-J.; Cai Q.-Y.; Lu Q.; Zhang Y.; Sun P.; Zhao M.; Chen H.-Z.; Lovell J. F.; Fang, C. Adv. Funct. Mater,2018, 28, 1801118.
[89] Choi Y. S.; Lee M. Y.; David A. E.; Park, Y. S. Mol. Cell. Toxicol.,2014, 10, 1.
[90] Sokolova V.; Epple, M. Angew. Chem. Int. Ed.,2008, 47, 1382.
[91] Guo X.; Huang, L. Acc. Chem. Res.,2012, 45, 971.
[92] Li,J.-X.; Geng,S.; Hu,S.-J.; Zhou,M.Chem. Eng. Prog 2023, 42, 2003 (in Chinese).
(李建雄, 耿爽, 胡树坚, 周明, 化工进展, 2023,42, 2003.)
[93] Kirpotin D.; Hong K.; Mullah N.; Papahadjopoulos D.; Zalipsky S. FEBS Lett,1996, 388, 115.
[94] Zhang X.; Zhao S.; Gao Z.; Zhou J.; Xia Y.; Tian J.; Shi C.; Wang Z. Nano Res.,2021, 14, 2432.
[95] Jiang L.; Li L.; He X.; Yi Q.; He B.; Cao J.; Pan W.; Gu Z. Biomaterials,2015, 52, 126.
[96] Wang C.; Zhang Y.; Dong, Y. Acc. Chem. Res.,2021, 54, 4283.
[97] Billingsley M. M.; Singh N.; Ravikumar P.; Zhang R.; June C. H.; Mitchell, M. J. Nano Lett.,2020, 20, 1578.
[98] Tenchov R.; Bird R.; Curtze A. E.; Zhou Q. ACS Nano,2021, 15, 16982.
[99] Shen,Y.; Hu,G.-X.; Zhang,H.-X.; Qi,L.-L.; Luo,C.-C.Acta Chim. Sinica 2013, 71 323 (in Chinese).
(沈银, 胡桂香, 张华星, 齐莉莉, 骆成才, 化学学报, 2013, 71, 323.)
[100] Fu Y.; Wang H.-J.; Zhang J.; Yu, X.-Q. Acta Chim. Sinica2013, 71, 585. (in Chinese).
(付云, 王海蛟, 张骥, 余孝其, 化学学报, 2013, 71, 585.)
[101] Cui,L.-L.; Zhang Y. Journal of Pharmacy2023, 58, 826 (in Chinese).
(崔丽莉, 张勇, 药学学报, 2023, 58, 826.)
[102] Yang M.; Zhang Z.; Jin P.; Jiang K.; Xu Y.; Pan F.; Tian K.; Yuan Z.; Liu X. E.; Fu J.; Wang B.; Yan H.; Zhan C.; Zhang, Z. Int. J. Pharm,2024, 650, 123695.
[103] Fenton O. S.; Kauffman K. J.; McClellan R. L.; Kaczmarek J. C.; Zeng M. D.; Andresen J. L.; Rhym L. H.; Heartlein M. W.; DeRosa F.; Anderson, D. G. Angew. Chem. Int. Ed.,2018, 57, 13582.
[104] Bragonzi A.; Boletta A.; Biffi A.; Muggia A.; Sersale G.; Cheng S. H.; Bordignon C.; Assael B. M.; Conese M.Gene Ther, 1999, 6, 1995.
[105] Cheng Q.; Wei T.; Farbiak L.; Johnson L. T.; Dilliard S. A.; Siegwart, D. J. Nat. Nanotechnol.,2020, 15, 4
[106] Li C.; Yang T.; Weng Y.; Zhang M.; Zhao D.; Guo S.; Hu B.; Shao W.; Wang X.; Hussain A.; Liang X.-J.; Huang Y. Bioact,2022, 9, 590.
[107] Chien P.-Y.; Wang J.; Carbonaro D.; Lei S.; Miller B.; Sheikh S.; Ali S. M.; Ahmad M. U.; Ahmad, I. Cancer Gene Ther,2005, 12, 3.
[108] Rosenblum D.; Gutkin A.; Kedmi R.; Ramishetti S.; Veiga N.; Jacobi A. M.; Schubert M. S.; Friedmann-Morvinski D.; Cohen Z. R.; Behlke M. A.; Lieberman J.; Peer D. Sci. Adv,2020, 6, eabc9450.
[109] Azarnezhad A.; Samadian H.; Jaymand M.; Sobhani M.; Ahmadi, A. Crit. Rev. Toxicol,2020, 50, 148.
[110] Nakamura T.; Nakade T.; Yamada K.; Sato Y.; Harashima, H. Int. J. Pharm,2021, 609, 121140.
[111] Peng L.; Wagner E. Biomacromolecules,2019, 20, 3613.
[112] Sunshine J. C.; Bishop C. J.; Green, J. J. Ther Deliv,2011, 2, 493.
[113] Kumar R.; Santa Chalarca C. F.; Bockman M. R.; Bruggen C. V.; Grimme C. J.; Dalal R. J.; Hanson M. G.; Hexum J. K.; Reineke, T. M. Chem. Rev.,2021, 121, 11527.
[114] Wei Z.; Zijian Y.; Wei, D. Chin J Org Chem,2018, 38, 2713 (in Chinese).
(张薇, 姚子健, 邓维, 有机化学, 2018, 38, 2713.)
[115] Creusat G.; Rinaldi A.-S.; Weiss E.; Elbaghdadi R.; Remy J.-S.; Mulherkar R.; Zuber G. Bioconjugate Chem.,2010, 21, 994.
[116] Kurtulus I.; Yilmaz G.; Ucuncu M.; Emrullahoglu M.; Remzi Becer C.; Bulmus V. Polym. Chem,2014, 5, 1593.
[117] Yezhelyev M. V.; Qi L.; O’Regan R. M.; Nie S.; Gao, X. J. Am. Chem. Soc.,2008, 130, 9006.
[118] Pandey A. P.; Sawant, K. K. Mater. Sci. Eng. C,2016, 68, 904.
[119] Wei Z.; Niwei X.; Zijian Y.; Kuan L.; Yu Z.; Liangyan C.; Wenling Y.; Wei D.Chin. J. Org. Chem, 2016, 36, 2039 (in Chinese).
(张薇, 徐妮为, 姚子健, 李宽, 朱玉, 陈良艳, 叶文玲, 邓维, 有机化学, 2016,36, 2039.)
[120] Bae Y.; Song S. J.; Mun J. Y.; Ko K. S.; Han J.; Choi J. S. Polymers,2017, 9, 6.
[121] Chen Q.; Su L.; He X.; Li J.; Cao Y.; Wu Q.; Qin J.; He Z.; Huang X.; Yang H.; Li J.Biomacromolecules, 2022, 23, 2116.
[122] Pu,X.; Li,Z.-J.; Shi,J.-X.; Zhu,Y.-Q.; Du J.-Z. Acta Chim. Sinica2023, 81, 1438 (in Chinese).
(溥旭, 李泽娟, 石隽秋, 朱云卿, 杜建忠, 化学学报, 2023, 81, 1438.)
[123] Dong Y.; Yao C.; Zhu Y.; Yang L.; Luo D.; Yang D. Chem. Rev.,2020, 120, 9420.
[124] Seeman N. C.; Sleiman, H. F. Nat Rev Mater,2017, 3, 17068.
[125] Edwardson T. G. W.; Lau K. L.; Bousmail D.; Serpell C. J.; Sleiman, H. F. Nature Chem,2016, 8, 162.
[126] Xie L.; Ding X.; Budry R.; Mao G. IJN,2018, Volume 13, 4943.
[127] Kumar S.; Garg P.; Pandey S.; Kumari M.; Hoon S.; Jang K.-J.; Kapavarapu R.; Choung P.-H.; Sobral A. J. F. N.; Hoon Chung, J. J. Mater. Chem. B,2015, 3, 3465.
[128] Von Erlach T.; Zwicker S.; Pidhatika B.; Konradi R.; Textor M.; Hall H.; Lühmann T. Biomaterials,2011, 32, 5291.
[129] Guo Y.; Zhang Q.; Zhu Q.; Gao J.; Zhu X.; Yu H.; Li Y.; Zhang C. Sci. Adv.,2022, 8, eabn2941.
[130] Wu X.; Yang C.; Wang H.; Lu X.; Shang Y.; Liu Q.; Fan J.; Liu J.; Ding, B. J. Am. Chem. Soc.,2023, 145, 9343.
[131] He Y.; Li D.; Wu L.; Yin X.; Zhang X.; Patterson L. H.; Zhang, J. Adv. Funct. Mater,2023, 33, 2212277.
[132] Lai,X.-Y.; Wang,Z.-Y.; Zheng,Y.-T.; Chen Y.-M. Prog Chem2019, 31, 783 (in Chinese).
(赖欣宜, 王志勇, 郑永太, 陈永明, 化学进展, 2019, 31, 783.)
[133] Duan L.; Xu L.; Xu X.; Qin Z.; Zhou X.; Xiao Y.; Liang Y.; Xia J. Nanoscale,2021, 13, 1387.
[134] Sun,B.; Ju,W.-W.; Wang,T.; Sun,X.-J.; Zhao,T.; Lu,X.-M.; Lu,F.; Fan Q.-L. Acta Chimica Sinica2023, 81,757 (in Chinese).
(孙博, 琚雯雯, 王涛, 孙晓军, 赵婷, 卢晓梅, 陆峰, 范曲立, 化学学报, 2023, 81, 757.)
[135] Qi X.-P.; Wang F.; Zhang, J. Acta Chimica Sinica2023, 81, 548 (in Chinese).
(齐学平, 王飞, 张健, 化学学报, 2023, 81, 548.)
[136] He C.; Lu K.; Liu D.; Lin, W. J. Am. Chem. Soc.,2014, 136, 5181.
[137] Zhao,L.-D.; Zuo,P.; Yin,B.-C.; Hong,C.-L.; Ye,B.-C.Acta Chimica Sinica 2020,78,1076 (in Chinese).
(赵丽东, 左鹏, 尹斌成, 洪成林, 叶邦策, 化学学报, 2020, 78, 1076.)
[138] Das C. K.; Jena B. C.; Banerjee I.; Das S.; Parekh A.; Bhutia S. K.; Mandal M. Mol. Pharmaceutics,2019, 16, 24.
[139] Kim S. M.; Yang Y.; Oh S. J.; Hong Y.; Seo M.; Jang, M. J Control Release,2017, 266, 8.

用于肝癌治疗的核酸药物递送体系研究进展

Advances in Nucleic Acid Drug Delivery Systems for Liver Cancer Treatment

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