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Synthesis and Biological Activities of Novel Benzoxazolinone/Benzothiazolone Derivatives Containing Oxadiazole Moiety

  • LI Ying-Jun ,
  • LI Chun-Yan ,
  • JIN Kun ,
  • SUN Shu-Qin ,
  • ZHOU Xiao-Xia
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  • a College of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian 116029;
    b State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012

Received date: 2011-05-30

  Revised date: 2011-07-25

  Online published: 2012-02-25

Supported by

Project supported by the Natural Science Foundation of Liaoning Province (No.20102126).

Abstract

Thirty novel benzoxazolinone/benzothiazolone derivatives (6) containing oxadiazole moiety were synthesized by 2-aminophenol or 2-minothiophenol and urea as starting materials via a series of reactions. The structures of new intermediate 4 and the target compounds 6 were characterized by IR, 1H NMR spectra and elemental analysis. The synthesized target compounds were screened for the anticancer, antiinflammatory and immunoregulatory activities. The results indicated that some compounds exhibited weak activities in the anticancer and immunoregulatory fields, while all of them were found to be inactive against TNF-α and Cdc25B phosphatase.

Cite this article

LI Ying-Jun , LI Chun-Yan , JIN Kun , SUN Shu-Qin , ZHOU Xiao-Xia . Synthesis and Biological Activities of Novel Benzoxazolinone/Benzothiazolone Derivatives Containing Oxadiazole Moiety[J]. Acta Chimica Sinica, 2012 , 70(02) : 151 -160 . DOI: 10.6023/A1105302

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