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Acta Chimica Sinica >

2012 , Vol. 70 >Issue 02: 183 - 189

DOI: https://doi.org/10.6023/A1109091

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Synthesis of a Brazilin Analog

  • PAN Cheng-Xue ,
  • GUAN Yi-Fu ,
  • ZHANG Hong-Bin
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  • a State Key Laboratory Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin 541004;
    b Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan University, Kunming 650091

Received date: 2011-09-09

  Revised date: 2011-10-18

  Online published: 2012-02-25

Supported by

National Basic Research Program of China (973 Program, No.2009CB522300).

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Abstract

In this paper the synthesis of a brazilin analog starting from 3-(3,4-dimethoxy-phenyl)-propionic acid is reported. The synthetic route was finished in 10 steps including intramolecular Friedel-Crafts acylation, dihydroxylation, Lombardo reaction, oxidation with hypervalent iodine compounds, semipinacol rearrangement reaction and so on.

Key words： brazilin; natural product analog; synthesis

Cite this article

PAN Cheng-Xue , GUAN Yi-Fu , ZHANG Hong-Bin . Synthesis of a Brazilin Analog[J]. Acta Chimica Sinica, 2012 , 70(02) : 183 -189 . DOI: 10.6023/A1109091

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