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Acta Chimica Sinica >

2012 , Vol. 70 >Issue 03: 297 - 302

DOI: https://doi.org/10.6023/A1111141

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Asymmetric Hydrogenation of Aromatic Ketones Catalyzed by Cinchona- and PPh3-Modified RuRh/γ-Al2O3

  • JIANG He-Yan ,
  • CHEN Hua
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  • a Research Center of Pharmaceutical Chemistry and Chemical Biology, Key Laboratory of Catalysis Science and Technology of Chongqing Education Commission, Chongqing Technology and Business University, Chongqing 400067;
    b Key Lab of Green Chemistry and Technology, Ministry of Education, The Institute of Homogeneous Catalysis, College of Chemistry, Sichuan University, Chengdu 610064

Received date: 2011-11-14

  Revised date: 2011-12-01

  Online published: 2011-12-01

Supported by

Project supported by Natural Science Foundation Project of CQ (No. CSTC, 2011BA5025), Ministry of Education of Chongqing (No. KJ100701), Chongqing Technology and Business University (No. 2010-56-14) and Chongqing Innovative Research Team Development Program in University (No. KJTD201020).

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Abstract

The asymmetric hydrogenation of aromatic ketones catalyzed by cinchona- and PPh3-modified 1.0% Ru+0.2% Rh/γ-Al2O3 was studied. The effects of different modifiers, modifier concentration, different base additives, base additive concentration, solvents, and hydrogen pressure on the asymmetric hydrogenation of aromatic ketones were investigated in detail. The results showed that cinchona alkaloids had good modification effects on the 1.0% Ru+0.2% Rh/γ-Al2O3-tpp catalyst. Under the optimum conditions, the hydrogenation enantioselectivity of acetophenone was up to 84%.

Key words： ruthenium; rhodium; cinchona alkaloids; aromatic ketones; asymmetric hydrogenation

Cite this article

JIANG He-Yan , CHEN Hua . Asymmetric Hydrogenation of Aromatic Ketones Catalyzed by Cinchona- and PPh3-Modified RuRh/γ-Al2O3[J]. Acta Chimica Sinica, 2012 , 70(03) : 297 -302 . DOI: 10.6023/A1111141

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