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Acta Chimica Sinica >

2012 , Vol. 70 >Issue 03: 357 - 362

DOI: https://doi.org/10.6023/A1107101

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Synthesis, Crystal Structure and Bacteriostatic Activity of M (M＝Co2+, Cd2+, Mn2+) Complex with 2,5-Bis(3,5- dimethylpyrazol-4-thio)-3,4-thiadiazole

  • ZHANG Qi-Long ,
  • YUAN Ze-Li ,
  • ZHANG Yun-Qian ,
  • ZHU Bi-Xue
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  • a Department of Chemistry, Guiyang Medical College, Guiyang 550004;
    b Department of Pharmacy, Zhunyi Medical College, Zhunyi 563003;
    c Key Laboratory of Macrocycle and Supramolecular Chemistry, Guiyang 550025

Received date: 2011-07-10

  Revised date: 2011-09-05

  Online published: 2011-10-25

Supported by

This work was supported by the National Natural Science Foundation of China (No. 21061003) and the Natural Science Foundation of Guizhou Province (No. [2011]2287).

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Abstract

Three complexes [Co(L)2(H2O)4](NO3)2·4(CH3CH2OH)(1), [Cd(L)2(H2O)4](NO3)2·4(CH3CH2- OH) (2) and [Mn(L)2(Cl)2(CH3OH)2]·2(CH3OH) (3) were synthesized from the reaction of 2,5-bis(3,5- dimethylpyrazol-4-thio)-3,4-thiadiazole with Co(NO3)2·6H2O, Cd(NO3)2·4H2O and MnCl2·4H2O, and characterized by elemental analysis, FT-IR and single crystal X-ray diffraction. The results of structural analysis indicate that the ligand (L) was adopted “U” configuration, and each complex shows a “S” conformation. In three complexes, the coordination environment of each metal center show a distorted octahedral geometry, and each metal ion was coordinated with two ligands. The bacteriostatic activity results indicated that both of the ligand and complexes possess some bacteriostatic effect.

Key words： complex; crystal structure; bacteriostatic activity

Cite this article

ZHANG Qi-Long , YUAN Ze-Li , ZHANG Yun-Qian , ZHU Bi-Xue . Synthesis, Crystal Structure and Bacteriostatic Activity of M (M＝Co2+, Cd2+, Mn2+) Complex with 2,5-Bis(3,5- dimethylpyrazol-4-thio)-3,4-thiadiazole[J]. Acta Chimica Sinica, 2012 , 70(03) : 357 -362 . DOI: 10.6023/A1107101

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