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Acta Chimica Sinica >

2012 , Vol. 0 >Issue 04: 479 - 484

DOI: https://doi.org/10.6023/A1108303

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Heparinized Silk Fibroin Scaffolds as the Sustained Release Carrier of Bone Morphogenetic Protein-2

  • Ma Yinsun ,
  • Cai Yurong ,
  • Liu Lin ,
  • Yao Juming
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  • The Key Laboratory of Advanced Textile Materials and Manufacturing Technology of Ministry of Education, College of Materials and Textiles, Zhejiang Sci-Tech University, Hangzhou 310018

Received date: 2011-08-30

  Revised date: 2011-10-10

  Online published: 2011-11-28

Supported by

Project supported by the National Natural Science Foundation of China (Nos. 21041003 and 51172207).

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Abstract

Sustained release carrier for the bone morphogenetic protein-2 (BMP-2) is currently a hot subject of research on the bone tissue engineering. In this work, two kinds of heparinized silk fibroin scaffolds were prepared. The binding ability to BMP-2, in vitro sustained release property and the alkaline phosphatase (ALP) activity of the scaffolds were investigated. Results showed that the heparinized silk fibroin scaffolds could bind BMP-2 well and sustained release the BMP-2. The scaffolds with BMP-2 could improve the MG-63 cell growth and cell differentiation with high ALP activity. So the heparinized silk fibroin scaffolds could be an ideal sustained release carrier for BMP-2.

Key words： silk fibroin scaffold; BMP-2; alkaline phosphatase; sustained release

Cite this article

Ma Yinsun , Cai Yurong , Liu Lin , Yao Juming . Heparinized Silk Fibroin Scaffolds as the Sustained Release Carrier of Bone Morphogenetic Protein-2[J]. Acta Chimica Sinica, 2012 , 0(04) : 479 -484 . DOI: 10.6023/A1108303

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