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Preparation and Properties of Amphiphilic Polymer Nanospheres Containing Aza-crown ether

  • Zhang Yujian ,
  • Xie Bin ,
  • Zhang Liyang ,
  • Ma Li ,
  • He Shuyan ,
  • Li Guowen
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  • a Daqing Petrochemical Research Center, Daqing 163714;
    b State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun 130012

Received date: 2011-05-16

  Revised date: 2011-08-15

  Online published: 2011-09-28

Supported by

Project supported by the National Natural Science Foundation of China (No. 20874037).

Abstract

An amphiphilic polymer containing adenine and aza-crown ethers, poly-{[N,N-bis(2-ethoxy)-1,10-diaza-18-crown-6][5-methylene-(1-adenine)]sophthaloyl ester} (PCASE), was synthesized. The SEM morphology observed indicates that the amphiphilic PCASE polymer self-organized into diameters of about 140~210 nm nanospheres in dilute aqueous solution after recognized with 5-fluorouracil spontaneously. The sizes of PCASE/5-flu nanospheres in dilute aqueous solution determined by dynamic light scattering (DLS) are mainly dispersed at 120~230 nm. The molecule recognition based on hydrogen bond between adenine of polymer and 5-fluorouracil substrate in PCASE/5-flu nanospheres was studied. After recognition the C(2)=O stretching vibration at 1724 cm-1 of 5-fluorouracil subtract shifted to 1718 cm-1, the NH2 stretching vibration at 3324 cm-1 disappeared, and a new peak at 3432 cm-1 arised, indicating the formation of hydrogen bonds between 5-fluorouracil and adenine in polymer PCASE.The study on variable temperature FTIR show that the peak 1718 cm-1 gradually shifted back to the position at 1724 cm-1, and the new peak 3432 cm-1 disappeared finally, indicating that the H-bond was broken.

Cite this article

Zhang Yujian , Xie Bin , Zhang Liyang , Ma Li , He Shuyan , Li Guowen . Preparation and Properties of Amphiphilic Polymer Nanospheres Containing Aza-crown ether[J]. Acta Chimica Sinica, 2012 , 0(04) : 499 -504 . DOI: 10.6023/A1105167

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