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Acta Chimica Sinica >

2012 , Vol. 0 >Issue 05: 674 - 678

DOI: https://doi.org/10.6023/A1108171

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Synthesis and in vitro Antitumor Activities of 6,7-Dimethoxy-4-piperazinquinazoline Thiosemicarbazone Derivatives

  • Liu Haibin ,
  • Xu Huijuan ,
  • L? Ping ,
  • Pan Ningning ,
  • Li Shuangqi
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  • School of Biomedical & Chemical Engineering, Liaoning Institute of Science and Technology, Benxi 117004

Received date: 2011-08-17

  Revised date: 2011-11-28

  Online published: 2011-11-29

Supported by

Project was supported by the Program of Liaoning Provincial Committee of Education (No. L2010204), the Program for Liaoning Excellent Talents in University (No. LJQ2011130) and the Ph. D. Program Foundation of Liaoning Institute of Science and Technology (No. 0906B1).

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Abstract

Six new quinazoline derivatives 4a～4f bearing thiosemicabazone have been designed and synthesized by four step reactions of cyclization, chlorination, substitution and condensation using 2-amino-4,5-dimethoxybenzoic acid and methanimidamide acetate as starting materials. Their structures were confirmed by 1H NMR, 13C NMR, ESI-MS, IR techniques and elemental analysis. The in vitro antitumor activities of compounds 4a～4f against SGC-7901 (human gastric cancer), KB (human oral epidermoid cancer) and HT-1080 (human fibrosarcoma) cell lines were tested using colorimetric MTT assay. The preliminary results indicated that compounds 4a and 4f showed significant antitumor activity against HT1080.

Key words： quinazoline; thiosemicarbazone; antitumor activity; MTT assay

Cite this article

Liu Haibin , Xu Huijuan , L? Ping , Pan Ningning , Li Shuangqi . Synthesis and in vitro Antitumor Activities of 6,7-Dimethoxy-4-piperazinquinazoline Thiosemicarbazone Derivatives[J]. Acta Chimica Sinica, 2012 , 0(05) : 674 -678 . DOI: 10.6023/A1108171

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