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Acta Chimica Sinica >

2012 , Vol. 70 >Issue 07: 843 - 851

DOI: https://doi.org/10.6023/A1110262

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Studies on the Determination Method of Pesticide Multi-residues in Ginseng by Ultra Performance Liquid Chromatography Tandem Mass Spectrometry

  • Chen Lina ,
  • Song Fengrui ,
  • Zheng Zhonga ,
  • Xing Junpeng ,
  • Liu Zhiqiang ,
  • Liu Shuying
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  • a Changchun Institute of Applied Chemistry Chinese Academy of Sciences, Changchun Centre of Mass Spectrometry, Changchun 130022;
    b Graduate School of Chinese Academy of Sciences, Beijing 100049

Received date: 2011-10-26

  Revised date: 2011-11-30

  Online published: 2012-01-05

Supported by

Project supported by the National Key Technology R&D Program in the 11th Five year Plan of China (No. 2009ZX09308-006) and Innovation Method Fund of China (No. 2010IM030400).

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Abstract

Taking the traditional herbal, ginseng, as the object in the paper, a comprehensive analytical method based on matrix solid-phase dispersion-ultra performance liquid chromatography tandem mass spectrometry (MSPD-UPLC-MS/MS) has been developed for the simultaneous determination of 46 pesticide residues in Ginseng. The sample was prepared by MSPD. Primary secondary amine (PSA) was used as dispersant, and acetonitrile was used as eluant. Both positive and negative ionization modes were used in the detection. Qualitative and quantitative analysis was carried out by UPLC-MS/MS under multiple reaction monitoring mode (MRM). The linear range of this method was 5～500.0 μg/kg. The limits of quantification (LOQ) for the 46 pesticides were less than 0.01 mg/kg. The mean recoveries at the three spiked levels of 10～100 μg/kg were 70%～110%, with relative standard deviations (RSD) better than 15% (n＝3). The method is robust, selective, sensitive, rapid and cheap.

Key words： matrix solid-phase dispersion; ultra performance liquid chromatography tandem mass spectrometry; ginseng; multi-residue pesticides

Cite this article

Chen Lina , Song Fengrui , Zheng Zhonga , Xing Junpeng , Liu Zhiqiang , Liu Shuying . Studies on the Determination Method of Pesticide Multi-residues in Ginseng by Ultra Performance Liquid Chromatography Tandem Mass Spectrometry[J]. Acta Chimica Sinica, 2012 , 70(07) : 843 -851 . DOI: 10.6023/A1110262

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