Special Topic

Study on Spectra of Interaction between Silicotungstic Acid and Palmatine Hydrochloride and Its Analysis Application

  • Li Huachun ,
  • Qin Mingli ,
  • Tan Kejun
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  • a Key Laboratory on Luminescence and Real-Time Analysis, Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715;
    b Nanchong Municipal Monitoring and Testing Center for Agricultural Product Quality, Nanchong 637000

Received date: 2011-09-30

  Revised date: 2011-12-03

  Online published: 2012-01-31

Supported by

Project was supported by the National Natural Science Foundation of China (No. 20877063) and the Large Instruments Open Foundation of Southwestern University (No. 201133).

Abstract

A novel resonance light scattering (RLS) method for the determination of palmatine hydrochloride (PaH) has been developed based on the largely enhanced RLS signals at 297 nm due to the interaction between Silicotungstic acid (STA) and PaH by electrostatic force in the pH 0.91 HCl-NaOAc medium. The linear range of PaH is 0.09~3.2 μg/mL. The limit of detection (LOD) is 9.1 ng/mL. In this work, the effects of pH and ionic strength on interaction were investigated. At the same time, the UV spectra, the fluorescence spectra and the reaction mechanism of system were also investigated. This method has been applied successfully for the determination of PaH in pharmaceutical and blood serum samples with RSD≤4.2%.

Cite this article

Li Huachun , Qin Mingli , Tan Kejun . Study on Spectra of Interaction between Silicotungstic Acid and Palmatine Hydrochloride and Its Analysis Application[J]. Acta Chimica Sinica, 2012 , 70(06) : 747 -752 . DOI: 10.6023/A1109301

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