Special Topic

Synthesis, Characterization and Biological Activity of Piperidinothienopyrimidinones

  • Zeng Guoping ,
  • Zheng Ping
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  • School of Chemistry and Life Sciences, Hubei University of Education, Wuhan 430205

Received date: 2011-08-22

  Revised date: 2011-10-21

  Online published: 2011-12-01

Supported by

Project supported by the Hubei Province Department of Education Scientific Research (No. B20113001), Hubei University of Education Key Disciplines “Applied Chemistry” (No. 201008).

Abstract

Nine new piperidinothienopyrimidinone derivatives were synthesized from the reaction of carbodiimide intermediate with primary, secondary amines and alcohols catalyzed by sodium alkoxide. The structures of the compound were confirmed by elemental analysis, 1H NMR, MS and single crystal X-ray determination. The fungicidal activities of all the compounds were studied and some compounds exhibited good bacteriostasis activity. Among them, compound 7b exhibited fungicidal activity against Botrytis cinereapers, Rhizoctonia solani, and Gibberella zeae with inhibitive rates of 76.19%, 68.83% and 56.52%, respectively.

Cite this article

Zeng Guoping , Zheng Ping . Synthesis, Characterization and Biological Activity of Piperidinothienopyrimidinones[J]. Acta Chimica Sinica, 2012 , 70(06) : 759 -764 . DOI: 10.6023/A1108221

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