Special Topic

Determination of Small Molecular Aldehydes in Cigarette Smoke by Extraction and Derivatization in Single Drop

  • Zhu Fengjun ,
  • Zhang Jing ,
  • Zheng Saijing ,
  • Liu Baizhan ,
  • Guo Yinlong
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  • a Shanghai Mass Spectrometry Center, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032;
    b Shanghai Tobacco Group Company, Shanghai 200082

Received date: 2012-02-22

  Revised date: 2012-04-19

  Online published: 2012-04-20

Supported by

Project supported by the National Natural Science Foundation of China (Nos. 20902104, 21072215, 21172250).

Abstract

Extraction and derivatization in single drop (EDSD) coupled to matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry (MALDI-FTICR-MS) was utilized to determine small molecular aldehydes in single puff smoke. Through employing Girard's reagent T as derivatization reagent, small molecular aldehydes (SMAs) transformed into quaternary ammonium salt, and the sensitivity of analysis for SMAs was significantly improved. Using this method, acetaldehyde and acrolein in single puff smoke were easily determined. This approach with an automatic potential provided a simple, rapid, and accurate procedure for the determination of SMAs in smoke.

Cite this article

Zhu Fengjun , Zhang Jing , Zheng Saijing , Liu Baizhan , Guo Yinlong . Determination of Small Molecular Aldehydes in Cigarette Smoke by Extraction and Derivatization in Single Drop[J]. Acta Chimica Sinica, 2012 , 70(12) : 1332 -1336 . DOI: 10.6023/A1202221

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