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Acta Chimica Sinica >

2012 , Vol. 70 >Issue 9: 1088 - 1094

DOI: https://doi.org/10.6023/A1108232

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Electrochemical Sensor for the Determination of Theophylline Based on Molecularly Imprinted Polymer with Ethylene Glycol Maleic Rosinate Acrylate as Cross-linker

  • Tan Xuecai ,
  • Wang Lin ,
  • Li Pengfei ,
  • Gong Qi ,
  • Liu Li Zhao Dandan ,
  • Lei Fuhou ,
  • Huang Zaiyin
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  • a. School of Chemistry and Chemical Engineering, Guangxi University for Nationalities, Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, Key Laboratory of Chemical and Biological Transforming Process in Universities of Guangxi, Nanning 530008;
    b. School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004

Received date: 2011-08-23

  Revised date: 2012-04-09

  Online published: 2012-04-18

Supported by

Project supported by the National Natural Science Foundation of China (Nos. 21065001, 30960306, 21165003), Guangxi Natural Science Foundation (Nos. 0991084, 0991001z), Scientific Reserch Fund of Guangxi Education Department (Nos. 200812MS074) and Guangxi Key Laboratory of Chemistry and Engineering of Forest Products (No. GXFC08-06).

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Abstract

A novel electrochemical sensor for the determination of theophylline based on ethylene glycol maleic rosinate acrylate as the cross linking agent and acrylic acid as functional monomer was fabricated by molecularly imprinted technology. A molecularly imprinted polymers (MIPs) membrane was synthesized on the surface of a glassy carbon electrode in vacuum drying oven by free radical polymerization method. The electrochemical behavior of the membrane was characterized by cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS) and chronoamperometry. Under optimum conditions, it was found that the response of peak currents was linear to the concentration of theophylline in range of 2.00×10-7～3.45×10-4 mol/L (linear regression coefficient＝0.9961) with the detection limit of 1.00×10-7 mol/L. The sensor not only has high selectivity, but also shows good stability and reproducibility. The sensor was applied to the determination of theophylline in theophylline sustained release tablets samples with recovery ranging from 95.6% to 103.8%.

Key words： ethylene glycol maleic rosinate acrylate; theophylline; molecularly imprinted polymer; electrochemical sensor

Cite this article

Tan Xuecai , Wang Lin , Li Pengfei , Gong Qi , Liu Li Zhao Dandan , Lei Fuhou , Huang Zaiyin . Electrochemical Sensor for the Determination of Theophylline Based on Molecularly Imprinted Polymer with Ethylene Glycol Maleic Rosinate Acrylate as Cross-linker[J]. Acta Chimica Sinica, 2012 , 70(9) : 1088 -1094 . DOI: 10.6023/A1108232

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