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Acta Chimica Sinica >

2013 , Vol. 71 >Issue 05: 717 - 721

DOI: https://doi.org/10.6023/A13020198

Article

Palladium-Catalyzed Decarboxylative ortho-Acylation of O-Methyl Ketoximes via Direct sp2 C—H Bond Activation

  • Cai Haiting ,
  • Li Dandan ,
  • Liu Zi ,
  • Wang Guanwu
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  • Department of Chemistry and Hefei National Laboratory for Physical Sciences at Microscale, University of Science and Technology of China, Hefei, Anhui 230026

Received date: 2013-02-19

  Online published: 2013-03-21

Supported by

Project supported by the National Natural Science Foundation of China (No. 91021004) and the Intercollegiate Key Project of Natural Sciences of Anhui Province, China (No. KJ2010ZD05).

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Abstract

The palladium-catalyzed decarboxylative ortho-acylation of O-methyl ketoximes with α-oxocarboxylic acids in the presence of Na2S2O8 and Ag2O is demonstrated. This protocol can be applied to various O-methyl ketoximes and α-oxocarboxylic acids with both electron-donating and electron-withdrawing groups with products yields up to 98%.

Key words： palladium catalysis; C—H bond activation; O-methyl ketoximes-directed; decarboxylation; acylation

Cite this article

Cai Haiting , Li Dandan , Liu Zi , Wang Guanwu . Palladium-Catalyzed Decarboxylative ortho-Acylation of O-Methyl Ketoximes via Direct sp2 C—H Bond Activation[J]. Acta Chimica Sinica, 2013 , 71(05) : 717 -721 . DOI: 10.6023/A13020198

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