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Acta Chimica Sinica >

2015 , Vol. 73 >Issue 12: 1302 - 1306

DOI: https://doi.org/10.6023/A15040263

Communication

Copper-Promoted Oxidative C-H Bond Amination of Hydrazones:Synthesis of 1H-Indazoles and 1H-Pyrazoles

  • Ding Zhengwei ,
  • Tan Qitao ,
  • Liu Bingxin ,
  • Zhang Kea ,
  • Xu Bin
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  • a Department of Chemistry, Shanghai University, Shanghai 200444;
    b State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032;
    c Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, Shanghai 200062

Received date: 2015-04-16

  Online published: 2015-06-15

Supported by

Project supported by the National Natural Science Foundation of China(Nos. 21272149, 21302123), Innovation Program of Shanghai Municipal Education Commission(No. 14ZZ094) and Science and Technology Commission of Shanghai Municipality(No. 13ZR1416400).

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Abstract

An efficient copper-promoted C(sp2)-H bond amination was developed to afford 1H-indazoles and 1H-pyrazoles in moderate to excellent yields from easily accessible hydrazones. This process tolerated a variety of functional groups and afforded the corresponding 1H-indazoles and 1H-pyrazoles under mild conditions.

Key words： C-H activation; amination; indazole; nitrogen heterocycles; pyrazole

Cite this article

Ding Zhengwei , Tan Qitao , Liu Bingxin , Zhang Kea , Xu Bin . Copper-Promoted Oxidative C-H Bond Amination of Hydrazones:Synthesis of 1H-Indazoles and 1H-Pyrazoles[J]. Acta Chimica Sinica, 2015 , 73(12) : 1302 -1306 . DOI: 10.6023/A15040263

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