Recent Development in Pd-Catalyzed meta-C(sp2)-H Bond Activation Based on Directing Strategy
Received date: 2015-05-10
Online published: 2015-06-29
Supported by
Project supported by the National Basic Research Program of China(973 Program, No. 2015CB856600), the National Natural Science Foundation of China(Nos. 21325206, 21172006), the National Young Top-notch Talent Support Program and the Programs Foundation of the Ministry of Education of China(No. 20120001110013).
In recent years, remarkable progress has been achieved in Pd-catalyzed meta-C(sp2)-H bond activation with directing groups. Based on remote activation strategy, a series of U-shaped directing groups have been devised by Yu and others and have been utilized in the olefination, arylation and acetoxylation of different types of substrates with the assistance of mono-protected amino acids(MPAA). Very recently, Yu reported the Pd-catalyzed meta-C(sp2)-H bond activation via the tandem reaction of ortho-C(sp2)-H bond activation and Catellani reaction using simple directing groups, in which alkylation and arylation could all be realized under the Pd/norbornene catalytic system. Dong and co-workers developed arylation of the meta-C(sp2)-H bond of N,N-dimethylbenzylamine with similar strategy. It is noteworthy that these above mentioned meta-C(sp2)-H bond activation protocols could be applied in the late-stage modification and the synthesis of some biologically active molecules and pharmaceutical intermediates. This manuscript will highlight the latest advances in Pd-catalyzed meta-C(sp2)-H bond activation with directing groups.
Yuan Yizhi , Song Song , Jiao Ning . Recent Development in Pd-Catalyzed meta-C(sp2)-H Bond Activation Based on Directing Strategy[J]. Acta Chimica Sinica, 2015 , 73(12) : 1231 -1234 . DOI: 10.6023/A15050319
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