Advances in Charge Transport through DNA Molecular Junction by Employing Electrodes Pair with Nanometer-sized Separation
Received date: 2019-04-11
Online published: 2019-05-21
Supported by
Project supported by the New Xiangya Talent Project of the Third Xiangya Hospital of Central South University(20150203);the National Key R&D Program of China(2017YFA0204902);the National Natural Science Foundation of China(21722305)
Molecular electronics is an interdisciplinary science that mainly studies the charge transport through molecules and its main goal is to fabricate molecular devices with electrical functionalities. In the state-of-art of molecular electronics, the research paradigm is to fabricate electrodes pair with nanometer-sized separation and construct the molecular junction through the assembly of target molecules with the electrodes pair. With this framework, the target molecule can be integrated to the macroscopic measurement circuit. DNA is one of the most significant biomolecules in natural sciences. It had drawn great attentions in biomedicine because of the carried genetic instructions. In molecular electronics, DNA also had attracted much interest due to the distinct structure and its capability of long-range charge transport. Nevertheless, in the early stage of molecular electronics, the probe molecules were limited to those with simple structures and short lengths. In recent years, molecular electronics had witnessed a rapid progress due to the developments in micro/nano-fabrication and the detection for weak current signal. Specifically, it includes the improvements in the success rate, efficiency, and stability of the fabricated molecular device. Benefiting from that, the probe molecules had been extended to a number of complex compounds like DNA. We give a brief introduction to the recent progress in the fabrication of DNA molecular junctions and the studies on the corresponding charge transport, most of which were made by using the research paradigm of fabricating electrodes pair with nanometer-sized separation. According to the fabrication methods that employed, these advances were introduced in two classes. One is that made by the as-called break junction methods, which include STM-break junction, conductive AFM and mechanically controllable break junction. The other is that made by the as-called cutting methods, which include cutting of carbon nanotube, graphene and silicon nanowire. We summarize the historical development of these methods and give a comparison between them. We also introduce some representative research on the charge transport through DNA molecular junction, and discuss the distinct features of DNA in electrical properties compared to the conventional small molecules. To conclude, we give a prospect on the future development of the studies on charge transport through DNA molecular junction.
Key words： molecular electronics; molecular junction; DNA; charge transport
Wei-Yu Yang, , Zhi-Chao Lei, , Wenjing Hong, , Fei-Zhou Huang, . Advances in Charge Transport through DNA Molecular Junction by Employing Electrodes Pair with Nanometer-sized Separation[J]. Acta Chimica Sinica, 2019 , 77(10) : 951 -963 . DOI: 10.6023/A19040127
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