Nanoprobes for Visualization of Cancer Pathology in Vivo※
Received date: 2021-12-31
Online published: 2022-03-10
Supported by
Youth Innovation Promotion Association CAS(2018042); National Key Research and Development Program of China(2018YFA0208800); National Natural Science Foundation of China(22177115); National Natural Science Foundation of China(81720108024); National Natural Science Foundation of China(82102679)
Cancer progression is often accompanied by a series of complicated variations of molecular pathology, varying enormously between individuals. Therefore, it is necessary to achieve precise diagnosis of tumor, especially at the molecular pathology level. In clinical trials, the traditional medical imaging can identify the position and the anatomical structure of tumors, but it is difficult to reveal their molecular pathology. Although the molecular details of tumors can be obtained later through the pathological analysis of biopsies, this approach is invasive and has spatiotemporal limitations. Unlike these strategies, the pathological biomarkers of tumors can be directly imaged in vivo through the probe-based molecular imaging technology, which aims to quantitatively study the real-time tumorous pathological features at a molecular level. This technology holds huge potentials in the clinical application of precise tumor diagnosis. In recent years, nanomaterials that possess superior optical or magnetic physicochemical properties have become one of the important signal carriers for constructing highly sensitive molecular imaging probes. In this review, the development of nanoprobe-based molecular imaging and the in vivo visualization of tumor molecular pathology are summarized. Specifically, the construction of the pathology responsive nanoprobes is highlighted. The current challenges and perspectives on the future steps needed to implement this nanotechnology in a clinical setting are also discussed.
Key words： pathology; tumor; nanoprobe; molecular imaging; visualization
Peisen Zhang , Lihong Jing . Nanoprobes for Visualization of Cancer Pathology in Vivo※[J]. Acta Chimica Sinica, 2022 , 80(6) : 805 -816 . DOI: 10.6023/A21120609
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