Research Progress in Preparation and Biomedical Application of Functional Medical Polyurethane Elastomers※
Received date: 2021-12-28
Online published: 2022-10-14
Supported by
National Natural Science Foundation of China(51973221); National Natural Science Foundation of China(51773218); National Key Research and Development Program of China(2020YFC1106900); Production Demonstration Platform for Biomedical Materials of Ministry of Industry and Information Technology of China(TC190H3ZV/1); Chinese Academy of Sciences-Wego Group Hightech Research & Development Program, Ningbo Technological Innovation 2025(2020Z086); Chinese Academy of Sciences-Wego Group Hightech Research & Development Program, Ningbo Technological Innovation 2025(2021Z070); Major Science and Technology Innovation Project of Shandong Province(2019JZZY011105)
Thermoplastic polyurethane (TPU) elastomer is widely used in biomedical field because of its good processability, mechanical property and biocompatibility. Most TPUs are composed of macromolecular diols as soft segments, diisocyanate and chain extenders as hard segments, which provide the elasticity of the matrix and the framework rigidity of the chain network, respectively. The structural design of chain extender diol/ diamine and diisocyanate is the main method to construct functional TPUs. Researchers designed and prepared the functional monomers according to the specific clinical scene or usage requirements, and developed the corresponding medical TPUs. In this paper, the types and characteristics of macromolecular diols, diisocyanate and chain extenders are introduced. Their unique microphase separation structures are analyzed, and the relationship between the chemical/physical structure and the final performance is discussed. Then, the research progress and advanced applications of TPU in biomedicine at home and abroad are summarized. The applications of TPU as antibacterial, anticoagulant, hydrolytic and oxidation resistant, self-healing and degradable materials are emphasized. Finally, by summarizing and analyzing various standards of biomedical TPU and its device, the key problems of industrial application are put forward, and the future development direction of TPU is prospected.
Zhenyan Zhang , Lin Liu , Donghua Xu , Ruoyu Zhang , Hengchong Shi , Shifang Luan , Jinghua Yin . Research Progress in Preparation and Biomedical Application of Functional Medical Polyurethane Elastomers※[J]. Acta Chimica Sinica, 2022 , 80(10) : 1436 -1447 . DOI: 10.6023/A21120593
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