Research Progress in Organic Reactions Involving 4-Acyl/Carbamoyl/Alkoxycarbonyl Substituted Hantzsch Esters
Received date: 2023-04-06
Online published: 2023-05-11
Supported by
National Natural Science Foundation of China(21702013); National Natural Science Foundation of China(22271010); Fundamental Research Funds for the Central Universities in BUCT(XK1802-6)
In recent years, 4-acyl/carbamoyl/alkoxycarbonyl-substituted Hantzsch esters have been increasingly utilized as a new class of radical precursor reagents, emerging as one of major research topics for synthetic chemists. These compounds can generate the corresponding acyl, carbamoyl, and alkoxycarbonyl radicals under mild conditions through photochemical, electrochemical, or chemical oxidation systems, leading to a wide array of radical addition/coupling reactions. Due to the reducibility of their dihydropyridine skeleton, these radical precursors often exhibit unique reactivities and display good compatibility with transition metal-catalysis and organocatalysis systems. In addition, the reported reaction conditions typically feature for environmental friendliness, highly functional group-tolerance, and biocompatibility, which should have significant research value in the fields of medicinal chemistry and chemical biology. Herein, this review summarizes the research progress of acyl, carbamoyl and alkoxycarbonyl radicals, and focuses on radical generation system, mechanistic underpinnings, as well as the uniqueness and applications of the synthetic strategies with such Hantzsch esters.
Li Liu , Gang Zheng , Guoqiang Fan , Hongguang Du , Jiajing Tan . Research Progress in Organic Reactions Involving 4-Acyl/Carbamoyl/Alkoxycarbonyl Substituted Hantzsch Esters[J]. Acta Chimica Sinica, 2023 , 81(6) : 657 -668 . DOI: 10.6023/A23040118
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