Modify a Fragment of Arctigenin with Pyrimidine Derivatives

doi:10.6023/cjoc201203001

Chin. J. Org. Chem. ›› 2012, Vol. 32 ›› Issue (10): 1894-1898.DOI: 10.6023/cjoc201203001 Previous Articles Next Articles

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嘧啶衍生物对牛蒡子苷元片段修饰的研究

王欢欢^a, 吴平^a, 康宏^b, 许亮^a, 朱瑞新^a,b, 康廷国^a

a 辽宁中医药大学药学院大连 116600;
b 同济大学生命科学与技术学院上海 200092

收稿日期:2012-03-19 修回日期:2012-05-29 发布日期:2012-10-27
通讯作者: 朱瑞新, 康廷国 E-mail:rxzhu@tongji.edu.cn
基金资助:
国家自然科学基金(No. 30976611)、中国高等教育博士研究基金计划(No. 20100072120050)和上海中药现代化(No. 09dZ1972800)资助项目.

Modify a Fragment of Arctigenin with Pyrimidine Derivatives

Wang Huanhuan^a, Wu Ping^a, Kang Hong^b, Xu Liang^a, Zhu Ruixin^a,b, Kang Tingguo^a

a School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116600;
b School of Life Sciences and Technology, Tongji University, Shanghai 200092

Received:2012-03-19 Revised:2012-05-29 Published:2012-10-27
Supported by:
Project supported by the National Natural Science Foundation of China (No. 30976611), the Research Fund for the Doctoral Program of Higher Education of China (No. 20100072120050) and the Traditional Chinese Medicine Modernization of Shanghai (No. 09dZ1972800).

In order to enhance the anti-tumor activity of the arctigenin and reduce the side effects of pyrimidine, arctigenin was modified with pyrimidine derivatives having biological activities. In this research, some halogenated pyrimidines were linked to the phenolic hydroxyl group of the arctigenin to gain eleven new compounds, and the structures of them were identified by LC-MS and ¹H NMR. So, the number of the anti-tumor compound libraries of compounds based on arctigenin was increased, and these compounds were prepared for the in-vitro activity screening in the near future. By our work, when enhance the alkalinity and increase the water content in DMF, the etherification reaction is promoted, to a certain extent.

Key words: arctigenin, structural modification, pyrimidine derivatives, nonidentical twin drug

Cite this article

Wang Huanhuan, Wu Ping, Kang Hong, Xu Liang, Zhu Ruixin, Kang Tingguo. Modify a Fragment of Arctigenin with Pyrimidine Derivatives[J]. Chin. J. Org. Chem., 2012, 32(10): 1894-1898.

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嘧啶衍生物对牛蒡子苷元片段修饰的研究

Modify a Fragment of Arctigenin with Pyrimidine Derivatives

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