Synthesis and Biological Evaluation of Quioline-Polyamine Derivatives

doi:10.6023/cjoc201209017

Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (01): 125-131.DOI: 10.6023/cjoc201209017 Previous Articles Next Articles

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喹啉-多胺衍生物的合成及其活性评价

罗稳^a, 张震^a,b, 王超杰^a

a 河南大学天然药物与免疫工程重点实验室开封 475004;
b 河南大学药学院开封 475004

收稿日期:2012-09-12 修回日期:2012-09-24 发布日期:2012-10-11
通讯作者: 王超杰 E-mail:wcjsxq@hehu.edu.cn
基金资助:
国家自然科学基金重大研究计划培育(No. 90913001)资助项目.

Synthesis and Biological Evaluation of Quioline-Polyamine Derivatives

Luo Wen^a, Zhang Zhen^a,b, Wang Chaojie^a

a Key Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, Henan University, Kaifeng 475004;
b Pharmaceutical College, Henan University, Kaifeng 475004

Received:2012-09-12 Revised:2012-09-24 Published:2012-10-11
Supported by:
Project supported by the National Natural Science Foundation of China (No. 90913001).

Thirteen quioline-polyamine derivatives were designed and synthesized. The structures of these compounds were confirmed by ¹H NMR, ESI-MS techniques and elemental analysis. The neurons protection activities of these compounds were evaluated by methyl thiazolyl tetrazolium (MTT) assay with sodium dithionite as an injury to adrenal pheochromocytoma (PC12) cells. The results showed that all the target compounds exhibited protection activity for PC12 cells and some of them were better than nimodipine. The best compounds were T6 and T7 with protection rates of 28.04% and 27.58%.

Key words: quioline, polyamine, cell protection

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Luo Wen, Zhang Zhen, Wang Chaojie. Synthesis and Biological Evaluation of Quioline-Polyamine Derivatives[J]. Chin. J. Org. Chem., 2013, 33(01): 125-131.

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喹啉-多胺衍生物的合成及其活性评价

Synthesis and Biological Evaluation of Quioline-Polyamine Derivatives

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