Highly Efficient Michael-Type Friedel-Crafts Reactions Catalyzed by Gold-bipyridine Complexes

doi:10.6023/cjoc201210030

Chin. J. Org. Chem. ›› 2012, Vol. 32 ›› Issue (12): 2283-2286.DOI: 10.6023/cjoc201210030 Previous Articles Next Articles

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金配合物催化的吲哚对α,β-不饱和酮的Friedel-Crafts烷基化反应

张艳^a,b, 朱成建^b

a 江南大学医药学院无锡 214122;
b 南京大学化学化工学院国家配位化学重点实验室南京 210093

收稿日期:2012-10-17 修回日期:2012-11-08 发布日期:2012-11-14
通讯作者: 张艳 E-mail:zhangyanchem@163.com
基金资助:
国家自然科学基金(Nos. 20832001, 20972065, 21074054)资助项目.

Highly Efficient Michael-Type Friedel-Crafts Reactions Catalyzed by Gold-bipyridine Complexes

Zhang Yan^a,b, Zhu Chengjian^b

a School of Medicine and Pharmaceutics, Jiangnan University, Wuxi 214122;
b State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093

Received:2012-10-17 Revised:2012-11-08 Published:2012-11-14
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 20832001, 20972065, 21074054).

A novel highly efficient gold-bipyridine catalyst system has been tested for Michael-type Friedel-Crafts reactions. Under the standard conditions, a series of chalcones bearing both electron-donating and electron-withdrawing substituents, reacted with indole to give the corresponding products. The protocol developed represents an efficient methodology for the Friedel-Crafts additions, which are extremely useful synthetic pathways and have widely been used in the construction of a variety of synthetically, as well as biologically important compounds.

Key words: gold complex, indole derivative, Friedel-Crafts addition, unsaturated ketone

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Zhang Yan, Zhu Chengjian. Highly Efficient Michael-Type Friedel-Crafts Reactions Catalyzed by Gold-bipyridine Complexes[J]. Chin. J. Org. Chem., 2012, 32(12): 2283-2286.

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金配合物催化的吲哚对α,β-不饱和酮的Friedel-Crafts烷基化反应

Highly Efficient Michael-Type Friedel-Crafts Reactions Catalyzed by Gold-bipyridine Complexes

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