An Efficient Synthesis of 2,3-Dihydrothiophene Derivatives from Four-Component Reactions under Catalyst-Free Conditions

doi:10.6023/cjoc201404009

Chin. J. Org. Chem. ›› 2014, Vol. 34 ›› Issue (9): 1895-1899.DOI: 10.6023/cjoc201404009 Previous Articles Next Articles

无催化剂条件下有效的四组分反应合成2,3-二氢噻吩衍生物

张金鹏^b, 高亚年^a, 陈明^a, 姜灵^a, 夏盛^a, 荣良策^a

a 江苏师范大学化学化工学院, 徐州 221116;
b 徐州医学院公共卫生学院, 徐州 221004

收稿日期:2014-04-03 修回日期:2014-04-29 发布日期:2014-05-07
通讯作者: 荣良策 E-mail:lcrong@jsnu.edu.cn; lcrong2005@yahoo.com
基金资助:
国家自然科学基础研究基金(No. 21172188)和江苏省功能性材料绿色合成重点实验室开放课题(No. K201312)资助项目.

An Efficient Synthesis of 2,3-Dihydrothiophene Derivatives from Four-Component Reactions under Catalyst-Free Conditions

Zhang Jinpeng^b, Gao Yanian^a, Chen Ming^a, Jiang Ling^a, Xia Sheng^a, Rong Liangce^a

a School of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou 221116;
b Department of Public Health, Xuzhou Medical College, Xuzhou 221004

Received:2014-04-03 Revised:2014-04-29 Published:2014-05-07
Supported by:
Project supported by the National Natural Science Foundation of China (No. 21172188), and the Open Foundation of Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials (No. K201312).

An efficient synthesis of 2,3-dihydrothiophene derivatives by the four-component reactions of aromatic aldehydes, thiazolidine-2,4-dione, malononitrile and pyridin-3-ylmethanamine has been reported. This reaction could be carried out smoothly without using any other catalysts in ethanol (95%) and the aromatic heterocyclic amine (pyridin-3-ylmethanamine) was first used for the synthesis of 2,3-dihydrothiophene derivatives. The advantages of this procure were mild reaction conditions, easy operation, and high yields. The products were identified by IR, ¹H NMR and HRMS.

Key words: thiophene, thiazolidine-2,4-dione, pyridin-3-ylmethanamine, four-component reactions

Cite this article

Zhang Jinpeng, Gao Yanian, Chen Ming, Jiang Ling, Xia Sheng, Rong Liangce. An Efficient Synthesis of 2,3-Dihydrothiophene Derivatives from Four-Component Reactions under Catalyst-Free Conditions[J]. Chin. J. Org. Chem., 2014, 34(9): 1895-1899.

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无催化剂条件下有效的四组分反应合成2,3-二氢噻吩衍生物

An Efficient Synthesis of 2,3-Dihydrothiophene Derivatives from Four-Component Reactions under Catalyst-Free Conditions

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