Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (9): 2204-2211.DOI: 10.6023/cjoc201601018 Previous Articles     Next Articles



沈薇a, 王林b, 陈敏a, 吴旻c, 包晓峰d   

  1. a 南京农业大学理学院 江苏省农药重点实验室 南京 210095;
    b 江苏科技大学环境与化工学院 镇江 212003;
    c 中国药科大学生科院 南京 210009;
    d 南京理工大学环境与生物工程学院 南京 210094
  • 收稿日期:2016-01-14 修回日期:2016-04-27 发布日期:2016-06-01
  • 通讯作者: 沈薇, 包晓峰
  • 基金资助:


A Highly Selective and Sensitive Pyrene Derivative 1-(Pyren-1-yl)-N,N-bis(pyridin-2-ylmethyl)methanamine Chemosensor for Zinc(Ⅱ) in the Presence of Pyrophosphatic Acid

Shen Weia, Wang Linb, Chen Mina, Wu Minc, Bao Xiaofengd   

  1. a Jiangsu Key Laboratory of Pesticide Science, Department of Science, Nanjing Agricultural university, Nanjing 210095;
    b School of Biology and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang 212003;
    c School of Life Science & Technology, China Pharmacutical University, Nanjing 210009;
    d Department of Biochemical Engineering, Nanjing University of Science & Technology, Nanjing 210094
  • Received:2016-01-14 Revised:2016-04-27 Published:2016-06-01
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No.21302098), and the Fundamental Research Funds for the Central Universities (No.KJQN201415).

A pyrene derivative PYPA, namely, 1-(pyren-1-yl)-N,N-bis(pyridin-2-ylmethyl)methanamine (PYPA), was synthesized to develop a chemosensor. The studies show that PYPA exhibits high sensitivity and selectivity toward Zn2+ over many other metal cations in the presence of pyrophosphatic acid (PPi). It has a low detection limit of 0.030 nmol/L. Detection of Zn2+ was not interfered by various cations or anions. In the presence of PPi, over a 8-fold fluorescence enhancement at 383 nm was observed within 20 s. Cell studies further demonstrated that PYPA can be a potential probe to detect Zn2+ in human liver cells (L-02).

Key words: pyrene derivative, Zn2+ fluorenscent probe, living cell image