Study of the Synthesis of α-Alkoxycarbonylaminomethylphosphonates

doi:10.6023/cjoc201701047

Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (8): 2073-2077.DOI: 10.6023/cjoc201701047 Previous Articles Next Articles

ARTICLE

α-烷氧酰胺亚甲基膦酸酯合成方法的研究

黄晓丽, 任林静, Sajjad Ali, 蒲家志, 姚秋丽

遵义医学院药学院遵义 563000

收稿日期:2017-01-25 修回日期:2017-03-08 发布日期:2017-04-13
通讯作者: 蒲家志, 姚秋丽 E-mail:yaoqiuli@zmc.edu.cn;872580024@qq.com
基金资助:
国家自然科学基金（No.21462056）、贵州省联合基金（No.[2014]7542）、贵州省大学生创新（No.201610661006）资助项目.

Study of the Synthesis of α-Alkoxycarbonylaminomethylphosphonates

Huang Xiaoli, Ren Linjing, Ali Sajjad, Pu Jiazhi, Yao Qiuli

School of Pharmacy, Zunyi Medical University, Zunyi 563000

Received:2017-01-25 Revised:2017-03-08 Published:2017-04-13
Contact: 10.6023/cjoc201701047 E-mail:yaoqiuli@zmc.edu.cn;872580024@qq.com
Supported by:
Project supported by the National Natural Science Foundation of China (No. 21462056), the Science and Technology Foundation of Guizhou Province (No.[2014]7542), and the Education Department of Guizhou Province (No. 201610661006).

1. Study of the Synthesis of α-Alkoxycarbonylaminomethylphosphonates.PDF(1143KB)

Abstract

Methods for the synthesis of α-alkoxycarbonylaminomethylphosphonates are very limited because of the presence of unique methylene group in their structures. Thus the methodology for the synthesis of this kind of compounds is studied. Under the basic conditions of using LiOH, α-sulfonylmethylcarbamates reacted with dialkylphosphonates in the solvent of commercial EtOAc giving the products of α-alkoxycarbonylaminomethylphosphonates which are typically hard to be synthesized in good to moderate yields. This simple protocol runs under very mild conditions, and can be exploited for multigram amounts with good yield too.

Key words: α-alkoxycarbonylaminomethylphosphonate, α-sulfonylmethylcarbamate, phosphonate

Cite this article

Huang Xiaoli, Ren Linjing, Ali Sajjad, Pu Jiazhi, Yao Qiuli. Study of the Synthesis of α-Alkoxycarbonylaminomethylphosphonates[J]. Chin. J. Org. Chem., 2017, 37(8): 2073-2077.

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α-烷氧酰胺亚甲基膦酸酯合成方法的研究

Study of the Synthesis of α-Alkoxycarbonylaminomethylphosphonates

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