Indium-Promoted Preparation of α-Methylene-γ-trifluoromethyl-γ-lactams via One-Pot Reaction

doi:10.6023/cjoc201703050

Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (11): 2985-2992.DOI: 10.6023/cjoc201703050 Previous Articles Next Articles

Articles

铟粉促进下“一锅法”合成α-亚甲基-γ-三氟甲基-γ-丁内酰胺化合物

李军, 黄丹凤, 张怀远, 张兴虎, 王娟娟, 王克虎, 苏瀛鹏, 胡雨来

西北师范大学化学化工学院兰州 730070

收稿日期:2017-03-30 修回日期:2017-07-03 发布日期:2017-07-14
通讯作者: 黄丹凤, 胡雨来 E-mail:huangdf@nwnu.edu.cn;huyl@nwnu.edu.cn
基金资助:
国家自然科学基金（Nos.21662030，21462037）资助项目.

Indium-Promoted Preparation of α-Methylene-γ-trifluoromethyl-γ-lactams via One-Pot Reaction

Li Jun, Huang Danfeng, Zhang Huaiyuan, Zhang Xinghu Wang Juanjuan, Wang Ke-Hu, Su Yingpeng, Hu Yulai

College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070

Received:2017-03-30 Revised:2017-07-03 Published:2017-07-14
Contact: 10.6023/cjoc201703050 E-mail:huangdf@nwnu.edu.cn;huyl@nwnu.edu.cn
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 21662030, 21462037).

1. Indium-Promoted Preparation of α-Methylene-γ-trifluoromethyl-γ-lactams via One-Pot Reaction.PDF(8361KB)

Abstract

An one-pot reaction of trifluoroacetaldehyde methyl hemiacetal or trifluoroketones, acylhydrazines and ethyl 2-(bromomethyl)acrylate promoted by indium powder has been investigated and a series of α-methylene-γ-trifluoromethyl-γ-lactams were obtained with high yieds. The features of this process include readily available starting materials as trifluoromethyl source, mild conditions and easy operation. The reaction provides a new method for the snythesis of trifluoromethylated α-methylene-γ-lactams.

Key words: one-pot, indium powder, trifluoroacetaldehyde methyl hemiacetal, trifluoroketone, 2-(bromomethyl) acrylate, arylacylhydrazine, α-methylene-γ-trifluoromethyl-γ-lactams

Cite this article

Li Jun, Huang Danfeng, Zhang Huaiyuan, Zhang Xinghu Wang Juanjuan, Wang Ke-Hu, Su Yingpeng, Hu Yulai. Indium-Promoted Preparation of α-Methylene-γ-trifluoromethyl-γ-lactams via One-Pot Reaction[J]. Chin. J. Org. Chem., 2017, 37(11): 2985-2992.

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铟粉促进下“一锅法”合成α-亚甲基-γ-三氟甲基-γ-丁内酰胺化合物

Indium-Promoted Preparation of α-Methylene-γ-trifluoromethyl-γ-lactams via One-Pot Reaction

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