Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (2): 350-362.DOI: 10.6023/cjoc201706018 Previous Articles     Next Articles

Special Issue: 元素有机化学合辑2018-2019 荧光探针-生物传感合辑 有机超分子化学合辑



卢博为a,b, 孟舒献a, 冯亚青a,b   

  1. a 天津大学化工学院 天津 300072;
    b 天津化学化工协同创新中心 天津 300072
  • 收稿日期:2017-06-15 修回日期:2017-09-11 发布日期:2017-10-11
  • 通讯作者: 孟舒献, 冯亚青;
  • 基金资助:


Progress of Fluorescent Bio-probe Based on Water-Soluble Boron-dipyrromethene

Lu Boweia,b, Meng Shuxiana, Feng Yaqinga,b   

  1. a School of Chemical Engineering, Tianjin University, Tianjin 300072;
    b Collaborative Innovation Center of Chemical Science and Engineering, Tianjin University, Tianjin 300072
  • Received:2017-06-15 Revised:2017-09-11 Published:2017-10-11
  • Contact: 10.6023/cjoc201706018;
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21676187).

Recently, the fluorescent bio-probe based on water-soluble boron-dipyrromethene (BODIPY) obtains enormous progress on structural optimization and functional modification, and becomes novel high-performance biological imaging materials owing to the development of hydrophilic modification. Focusing on the methods for improving the hydrophilicity of BODIPY, the water-soluble BODIPYs have been classified as ionic probe, electrically-neutral probe and amphiphilic probe. The research progress on the application of water-soluble BODIPY dyes in field of biology and medicine since 2006 has been summarized in this review, such as detection of necessary and pathogenicbiological chemical components, early detection and intervention of cancer, labelling drug delivery, marking specific organelles, real-time monitoring of biochemical and property changes with cells, andphotodynamic therapy. The merits of methods for improving the hydrophilicity and main issues of current studies have been summed up. The hypothesis for future directions has also been put forward.

Key words: boron-dipyrromethene (BODIPY), fluorescent bio-probe, water-soluble, biological imaging