Highly Efficent Synthesis of Novel Gastrodine Intermediate Analogues

doi:10.6023/cjoc201804005

Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (11): 3118-3122.DOI: 10.6023/cjoc201804005 Previous Articles Next Articles

Notes

新型天麻素中间体类似物的高效合成

许招会^a, 李瑜钰^a, 刘德永^a, 肖强^b

a 江西师范大学化学化工学院南昌 330027;
b 江西省人民医院骨科南昌 330006

收稿日期:2018-04-02 修回日期:2018-05-15 发布日期:2018-07-05
通讯作者: 许招会 E-mail:gotoxzh@163.com
基金资助:
Project supported by the National Natural Science Foundation of China (No. 81760297), the Graduate Innovation Fundation of Jiangxi Province (No. YC2015-B023) and the Science and Technology Research Project of Jiangxi Provincial Education Department (No. GJJ170170).

Highly Efficent Synthesis of Novel Gastrodine Intermediate Analogues

Xu Zhaohui^a, Li Yuyu^a, Liu Deyong^a, Xiao Qiang^b

a Department of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330027;
b Department of Orthpaedics, Jiangxi Province People's Hospital, Nanchang 330006

Received:2018-04-02 Revised:2018-05-15 Published:2018-07-05
Supported by:
Project supported by the National Natural Science Foundation of China (No. 81760297), the Graduate Innovation Fundation of Jiangxi Province (No. YC2015-B023) and the Science and Technology Research Project of Jiangxi Provincial Education Department (No. GJJ170170).

1. Highly Efficent Synthesis of Novel Gastrodine Intermediate Analogues.PDF(23091KB)

Abstract

Ten gastrodine intermediate analogues were synthesized by the Knoevenagel reaction of 4-formylphenyl(2,3,4,6-tetra-O-acetyl)-β-D-glucoside and 1,3-dioxane-4,6-dione with gluconic acid as a catalyst. In this reaction there are many advantages with good to excellent yields (78%~92%), mild conditions, simple operations and environmental friendliness. Additionally, gluconic acid could be recycled and reused many times without lossing its efficiency.

Key words: gluconic acid, Knoevenagel reaction, 4-formylphenyl (2,3,4,6-tetra-O-acetyl)-β-D-glucoside, gastrodine intermediate analogues

Cite this article

Xu Zhaohui, Li Yuyu, Liu Deyong, Xiao Qiang. Highly Efficent Synthesis of Novel Gastrodine Intermediate Analogues[J]. Chin. J. Org. Chem., 2018, 38(11): 3118-3122.

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新型天麻素中间体类似物的高效合成

Highly Efficent Synthesis of Novel Gastrodine Intermediate Analogues

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