Recent Progress on Direct Difluoromethylthiolation and Monofluoromethylthiolation

doi:10.6023/cjoc201907028

Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (1): 1-14.DOI: 10.6023/cjoc201907028 Previous Articles Next Articles

直接二氟甲硫基化与一氟甲硫基化反应研究进展

闫强, 蒋绿齐, 易文斌

南京理工大学化工学院南京 210094

收稿日期:2019-07-20 修回日期:2019-08-29 发布日期:2019-09-12
通讯作者: 蒋绿齐, 易文斌 E-mail:lvqi.jiang@njust.edu.cn;yiwb@njust.edu.cn
基金资助:
国家自然科学基金（No.21476116）、中央高校基本科研业务费专项资金（No.30918011314）、江苏省自然科学基金（No.BK20141394）和江苏省青蓝计划和六大高峰人才资助项目.

Recent Progress on Direct Difluoromethylthiolation and Monofluoromethylthiolation

Yan Qiang, Jiang Lüqi, Yi Wenbin

Chemical Engineering College, Nanjing University of Science and Technology, Nanjing 210094

Received:2019-07-20 Revised:2019-08-29 Published:2019-09-12
Supported by:
Project supported by the National Natural Science Foundation of China (No. 21476116), the Fundamental Research Funds for the Central Universities (No. 30918011314), the Natural Science Foundation of Jiangsu Province (No. BK20141394) and the Qing Lan and Six Talent Peaks in Jiangsu Province.

Compounds bearing difluoromethylthio (SCF₂H) and monofluoromethylthio (SCFH₂) groups are potentially important targets in the pharmaceutical and agrochemical fields due to their unique physical and chemical properties. The traditional methods of synthesizing these two kinds of compounds are difluoromethylation and monofluoromethylation of sulfhydryl substrates. However, the limitation of sulfhydryl substrates also limited the application and development of such compounds. Thus, it is still highly desirable to develop new methods for difluoromethylthiolation and monofluoromethylthiolation as well as new types of difluoromethylthiolation and monofluoromethylthiolation reagents. The recent development of direct difluoromethylthiolation and monofluoromethylthiolation reactions is summarized, and the related mechanism are also discussed.

Key words: difluoromethylthiolation, monofluoromethylthiolation, direct method

Cite this article

Yan Qiang, Jiang Lüqi, Yi Wenbin. Recent Progress on Direct Difluoromethylthiolation and Monofluoromethylthiolation[J]. Chinese Journal of Organic Chemistry, 2020, 40(1): 1-14.

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直接二氟甲硫基化与一氟甲硫基化反应研究进展

Recent Progress on Direct Difluoromethylthiolation and Monofluoromethylthiolation

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