Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (2): 447-453.DOI: 10.6023/cjoc201907037 Previous Articles     Next Articles


陆雨函, 韩颖芝, 孙亚栋, 阿布力米提·阿布都卡德尔, 王多志, 刘晨江   

  1. 新疆大学化学与化工学院 乌鲁木齐 830046
  • 收稿日期:2019-07-26 修回日期:2019-09-16 发布日期:2019-10-12
  • 通讯作者: 孙亚栋, 王多志;
  • 基金资助:

Application of Iodobenzene Acetate Promoted Oxidation in the Synthesis of 2-Amino-1,3,4-thiadiazole Molecules

Lu Yuhan, Han Yingzhi, Sun Yadong, Abdukader Ablimit, Wang Duozhi, Liu Chenjiang   

  1. College of Chemistry and Chemical Engineering, Xinjiang University, Urumqi 830046
  • Received:2019-07-26 Revised:2019-09-16 Published:2019-10-12
  • Supported by:
    Project supported by the National Natural Science Foundation of China (Nos. 21662032, 21562039) and the Xinjiang University Doctoral Science Foundation (No. BS150225).

A highly method for intramolecular oxidative coupling reaction of thiosemicarbazone promoted by hypervalent iodine reagent was reported. 2-Amino-1,3,4-thiadiazole derivatives could be synthesized effectively. Hypervalent iodine could be used as a mild reagent with low toxicity, low cost, easy circulation and operation. The reaction had the advantages of easy preparation of raw materials, simple operation and better performance. The applicability of substrates and the reaction mechanism were also preliminarily studied.

Key words: hypervalent iodine, oxidation, aromatic aldehydes, thiadiazole