I2/CuO-Catalyzed One-Pot Synthesis of 3-(2-Amino-4-thiazolyl) Coumarin Derivatives from 3-Acetylcoumarins and Thiourea

doi:10.6023/cjoc201908031

Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (4): 1068-1073.DOI: 10.6023/cjoc201908031 Previous Articles Next Articles

I₂/CuO催化的3-乙酰基香豆素和硫脲一锅反应合成3-(2-氨基-4-噻唑基)香豆素衍生物

赵芳, 胡洋, 李巧, 胡胜利

湖北师范大学化学化工学院黄石 435002

收稿日期:2019-08-23 修回日期:2019-10-19 发布日期:2019-11-07
通讯作者: 胡胜利 E-mail:hushengli168@126.com
基金资助:
湖北省高校优秀中青年科技创新团队（No.T201311）和湖北省教育厅（No.D20112507）资助项目.

I₂/CuO-Catalyzed One-Pot Synthesis of 3-(2-Amino-4-thiazolyl) Coumarin Derivatives from 3-Acetylcoumarins and Thiourea

Zhao Fang, Hu Yang, Li Qiao, Hu Shengli

College of Chemistry and Chemical Engineering, Hubei Normal University, Huangshi 435002

Received:2019-08-23 Revised:2019-10-19 Published:2019-11-07
Supported by:
Project supported by the Science Technology Foundation for Creative Research Group of Hubei Department of Education (No. T201311) and the Foundation of Hubei Provincal Ministry of Education (No. D20112507).

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Abstract

Coumarin and thiazole are two classes of important heterocycles with many biological activities and pharmacological effects. It is very meaningful to synthesize thiazolyl coumarin derivatives in medicinal chemistry area. In this study, a facile and efficient one-pot process was developed to synthesize substituted aminothiazoles from 3-acetylcoumarins and thiourea/N-substituted thioureas under the media of I₂/CuO. All target molecules were characterized by NMR, IR spectra and MS.

Key words: coumarin, 2-aminothiazole, one-pot reaction, I₂/CuO

Cite this article

Zhao Fang, Hu Yang, Li Qiao, Hu Shengli. I₂/CuO-Catalyzed One-Pot Synthesis of 3-(2-Amino-4-thiazolyl) Coumarin Derivatives from 3-Acetylcoumarins and Thiourea[J]. Chinese Journal of Organic Chemistry, 2020, 40(4): 1068-1073.

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I₂/CuO催化的3-乙酰基香豆素和硫脲一锅反应合成3-(2-氨基-4-噻唑基)香豆素衍生物

I₂/CuO-Catalyzed One-Pot Synthesis of 3-(2-Amino-4-thiazolyl) Coumarin Derivatives from 3-Acetylcoumarins and Thiourea

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I2/CuO催化的3-乙酰基香豆素和硫脲一锅反应合成3-(2-氨基-4-噻唑基)香豆素衍生物